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cacna1db calcium channel, voltage-dependent, L type, alpha 1D subunit, b [ Danio rerio (zebrafish) ]

Gene ID: 403311, updated on 9-Sep-2025
Official Symbol
cacna1dbprovided by ZNC
Official Full Name
calcium channel, voltage-dependent, L type, alpha 1D subunit, bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040525-3
See related
AllianceGenome:ZFIN:ZDB-GENE-040525-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cacna1d; cav1.3b
Summary
Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Predicted to be involved in calcium ion import; membrane depolarization during action potential; and positive regulation of calcium ion-dependent exocytosis. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in atrium and cardiac ventricle. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See cacna1db in Genome Data Viewer
Location:
chromosome: 8
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 8 NC_133183.1 (63413040..63478437)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 8 NC_007119.7 (53406021..53470174)

Chromosome 8 - NC_133183.1Genomic Context describing neighboring genes Neighboring gene BICD cargo adaptor 2a Neighboring gene decapping mRNA 1A Neighboring gene choline dehydrogenase Neighboring gene interleukin 17 receptor B

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. gemini encodes a zebrafish L-type calcium channel that localizes at sensory hair cell ribbon synapses. Sidi S, et al. J Neurosci, 2004 Apr 28. PMID 15115817, Free PMC Article
  2. Identification of calcium channel alpha1 subunit mRNA expressed in retinal bipolar neurons. Logiudice L, et al. Mol Vis, 2006 Mar 17. PMID 16568031, Free PMC Article
  3. LOF variants identifying candidate genes of laterality defects patients with congenital heart disease. Liu S, et al. PLoS Genet, 2022 Dec. PMID 36459505, Free PMC Article
  4. Expression of voltage-activated calcium channels in the early zebrafish embryo. Sanhueza D, et al. Zygote, 2009 May. PMID 19222870
  5. Expression of calcium channel transcripts in the zebrafish heart: dominance of T-type channels. Haverinen J, et al. J Exp Biol, 2018 May 20. PMID 29739832

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables low voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane depolarization during action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated sodium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
calcium channel, voltage-dependent, L type, alpha 1D subunit, b; voltage-dependent L-type calcium channel subunit alpha-1D
Names
calcium voltage-gated channel subunit alpha1 D

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133183.1 Reference GRCz12tu Primary Assembly

    Range
    63413040..63478437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073911288.1 → XP_073767389.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X2

  2. XM_073911293.1 → XP_073767394.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X7

  3. XM_073911309.1 → XP_073767410.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X21

  4. XM_073911292.1 → XP_073767393.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X6

  5. XM_073911298.1 → XP_073767399.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X11

  6. XM_073911308.1 → XP_073767409.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X20

  7. XM_073911305.1 → XP_073767406.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X18

  8. XM_073911312.1 → XP_073767413.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X24

  9. XM_073911287.1 → XP_073767388.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1

    UniProtKB/TrEMBL
    A0A8M9QJ57

  10. XM_073911294.1 → XP_073767395.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X8

  11. XM_073911290.1 → XP_073767391.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X4

  12. XM_073911303.1 → XP_073767404.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X16

  13. XM_073911301.1 → XP_073767402.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X14

  14. XM_073911310.1 → XP_073767411.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X22

  15. XM_073911289.1 → XP_073767390.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X3

  16. XM_073911299.1 → XP_073767400.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X12

  17. XM_073911297.1 → XP_073767398.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X10

  18. XM_073911291.1 → XP_073767392.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X5

  19. XM_073911302.1 → XP_073767403.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X15

  20. XM_073911300.1 → XP_073767401.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X13

  21. XM_073911313.1 → XP_073767414.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X25

  22. XM_073911295.1 → XP_073767396.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X9

  23. XM_073911306.1 → XP_073767407.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X19

  24. XM_073911304.1 → XP_073767405.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X17

  25. XM_073911311.1 → XP_073767412.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X23

  26. XM_073911314.1 → XP_073767415.1  voltage-dependent L-type calcium channel subunit alpha-1D isoform X26

RNA

  1. XR_012384808.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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