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OR2T35 olfactory receptor family 2 subfamily T member 35 [ Homo sapiens (human) ]

Gene ID: 403244, updated on 17-Jun-2024

Summary

Official Symbol
OR2T35provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily T member 35provided by HGNC
Primary source
HGNC:HGNC:31257
See related
Ensembl:ENSG00000177151 AllianceGenome:HGNC:31257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR2T35 in Genome Data Viewer
Location:
1q44
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248636356..248645278, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (248074945..248083605, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248799657..248808579, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily T member 10 Neighboring gene olfactory receptor family 2 subfamily T member 11 Neighboring gene olfactory receptor family 2 subfamily T member 27 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:248839638-248840292 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:248840293-248840946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2872 Neighboring gene olfactory receptor family 14 subfamily I member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2873 Neighboring gene LY6/PLAUR domain containing 9, pseudogene

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
olfactory receptor 2T35
Names
olfactory receptor OR1-66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001827.2NP_001001827.1  olfactory receptor 2T35

    See identical proteins and their annotated locations for NP_001001827.1

    Status: VALIDATED

    Source sequence(s)
    AC098483
    Consensus CDS
    CCDS31123.1
    UniProtKB/Swiss-Prot
    Q6IEY7, Q8NGX2
    UniProtKB/TrEMBL
    A0A126GWB5
    Related
    ENSP00000492995.1, ENST00000641268.1
    Conserved Domains (2) summary
    pfam00001
    Location:43290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34305
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    248636356..248645278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791755.1 Reference GRCh38.p14 PATCHES

    Range
    278207..286866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    248074945..248083605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)