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Defb21 defensin beta 21 [ Mus musculus (house mouse) ]

Gene ID: 403172, updated on 8-Dec-2022

Summary

Official Symbol
Defb21provided by MGI
Official Full Name
defensin beta 21provided by MGI
Primary source
MGI:MGI:2684967
See related
Ensembl:ENSMUSG00000056544 AllianceGenome:MGI:2684967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm121; 4930525K10Rik
Summary
Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-negative bacterium; and membrane disruption in other organism. Is expressed in forelimb bud. Orthologous to human DEFB118 (defensin beta 118). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward genital fat pad adult (RPKM 67.6) See more
Orthologs
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Genomic context

See Defb21 in Genome Data Viewer
Location:
2; 2 H1
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152414663..152416864)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152572743..152574944)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene defensin beta 29 Neighboring gene predicted gene 14161 Neighboring gene defensin beta 19 Neighboring gene defensin beta 45

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379477.1NP_001366406.1  beta-defensin 118 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5 UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL845162
    UniProtKB/TrEMBL
    Q8C5Z4
    Conserved Domains (1) summary
    pfam13841
    Location:3362
    Defensin_beta_2; Beta defensin
  2. NM_207276.3NP_997159.1  beta-defensin 118 precursor

    See identical proteins and their annotated locations for NP_997159.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL845162
    Consensus CDS
    CCDS16890.1
    UniProtKB/TrEMBL
    Q8C5Z4
    Related
    ENSMUSP00000065102.3, ENSMUST00000070722.3
    Conserved Domains (1) summary
    pfam13841
    Location:3362
    Defensin_beta_2; Beta defensin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152414663..152416864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)