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has1 hyaluronan synthase 1 [ Danio rerio (zebrafish) ]

Gene ID: 403130, updated on 9-Sep-2025
Official Symbol
has1provided by ZNC
Official Full Name
hyaluronan synthase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040218-2
See related
Ensembl:ENSDARG00000042983 AllianceGenome:ZFIN:ZDB-GENE-040218-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable hyaluronan synthase activity. Predicted to be involved in extracellular matrix assembly; hyaluronan biosynthetic process; and polysaccharide biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human HAS1 (hyaluronan synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See has1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 16 NC_133191.1 (26233121..26241495, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 16 NC_007127.7 (24939631..24946162, complement)

Chromosome 16 - NC_133191.1Genomic Context describing neighboring genes Neighboring gene sperm acrosome associated 6 Neighboring gene microRNA let7d-1 Neighboring gene uncharacterized LOC141378068 Neighboring gene microRNA 125a-1 Neighboring gene si:dkeyp-84f3.5 Neighboring gene formyl peptide receptor 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. A systematic toxicity evaluation of cephalosporins via transcriptomics in zebrafish and in silico ADMET studies. Han Y, et al. Food Chem Toxicol, 2018 Jun. PMID 29689360
  2. Cx43-Dependent Skeletal Phenotypes Are Mediated by Interactions between the Hapln1a-ECM and Sema3d during Fin Regeneration. Govindan J, et al. PLoS One, 2016. PMID 26828861, Free PMC Article
  3. Structure-toxicity relationship of cefoperazone and its impurities to developing zebrafish by transcriptome and Raman analysis. Han Y, et al. Toxicol Appl Pharmacol, 2017 Jul 15. PMID 28465218
  4. Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Bakkers J, et al. Development, 2004 Feb. PMID 14729574
  5. Triclocarban triggers osteoarthritis via DNMT1-mediated epigenetic modification and suppression of COL2A in cartilage tissues. Zhang Y, et al. J Hazard Mater, 2023 Apr 5. PMID 36680903

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hyaluronan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronan synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables hyaluronan synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hyaluronan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hyaluronan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
hyaluronan synthase 1
NP_001157502.1
XP_021322342.3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164030.1 → NP_001157502.1  hyaluronan synthase 1

    Status: PROVISIONAL

    Source sequence(s)
    JBMGRA010000016
    UniProtKB/TrEMBL
    A0A8M1NV47, A0A8M9NZ80, X1WCR3
    Related
    ENSDARP00000128010.1, ENSDART00000154004.2
    Conserved Domains (2) summary
    COG1215
    Location:38 → 535
    BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
    cl11394
    Location:92 → 379
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133191.1 Reference GRCz12tu Primary Assembly

    Range
    26233121..26241495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466667.3 → XP_021322342.3  hyaluronan synthase 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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