Format

Send to:

Choose Destination

braf B-Raf proto-oncogene, serine/threonine kinase [ Danio rerio (zebrafish) ]

Gene ID: 403065, updated on 17-Nov-2020

Summary

Official Symbol
brafprovided by ZNC
Official Full Name
B-Raf proto-oncogene, serine/threonine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040805-1
See related
Ensembl:ENSDARG00000017661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sierrabraf
Orthologs

Genomic context

See braf in Genome Data Viewer
Location:
chromosome: 4
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (12072421..12102123, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (12073572..12103187, complement)
103 previous assembly Zv9 (GCF_000002035.4) 4 NC_007115.5 (11138779..11166636, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:dkey-222f8.3 Neighboring gene uncharacterized LOC101883576 Neighboring gene troponin T2c, cardiac Neighboring gene uncharacterized LOC108183387 Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene transmembrane protein 178B

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase B-raf
Names
serine/threonine protein kinase BRAF
v-raf murine sarcoma viral oncogene homolog B1
NP_001311445.1
NP_991307.3
XP_021330649.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324516.1NP_001311445.1  serine/threonine-protein kinase B-raf isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX005210
    UniProtKB/TrEMBL
    Q1LYG2
    Related
    ENSDARP00000048390.8, ENSDART00000048391.10
    Conserved Domains (4) summary
    cd01816
    Location:166237
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14062
    Location:513765
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:245290
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam07714
    Location:507764
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_205744.4NP_991307.3  serine/threonine-protein kinase B-raf isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC162198, BX005210
    UniProtKB/TrEMBL
    B3DFX5
    Related
    ENSDARP00000016253.10, ENSDART00000023894.11
    Conserved Domains (4) summary
    cd01816
    Location:166237
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd14151
    Location:458731
    STKc_B-Raf; Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00130
    Location:245290
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam07714
    Location:467724
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    12072421..12102123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474974.1XP_021330649.1  serine/threonine-protein kinase B-raf isoform X1

    Related
    ENSDART00000132650.2
    Conserved Domains (3) summary
    cd01816
    Location:166237
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    pfam00130
    Location:245290
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl21453
    Location:458575
    PKc_like; Protein Kinases, catalytic domain
Support Center