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araf A-Raf proto-oncogene, serine/threonine kinase [ Danio rerio (zebrafish) ]

Gene ID: 403063, updated on 17-Nov-2020

Summary

Official Symbol
arafprovided by ZNC
Official Full Name
A-Raf proto-oncogene, serine/threonine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050102-2
See related
Ensembl:ENSDARG00000054533
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:eu99; sb:eu994; zgc:92074; wu:fk45h07
Orthologs

Genomic context

See araf in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (26853069..26869389)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (26252387..26269036)
103 previous assembly Zv9 (GCF_000002035.4) 5 NC_007116.5 (28497390..28513939)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:ch211-102c2.4 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 4 Neighboring gene zgc:64051 Neighboring gene lectin, mannose-binding 2-like b

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SMAD binding IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nodal signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of nodal signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase A-Raf
Names
serine/threonine protein kinase ARAF alt1
serine/threonine protein kinase ARAF alt2
serine/threonine protein kinase ARAF alt3
serine/threonine protein kinase ARAF alt4
serine/threonine protein kinase ARAF alt5
serine/threonine protein kinase ARAF standard form
truncated ARAF protein
v-raf murine sarcoma 3611 viral oncogene homolog
NP_991306.1
XP_005171874.1
XP_005171875.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205743.1NP_991306.1  serine/threonine-protein kinase A-Raf

    See identical proteins and their annotated locations for NP_991306.1

    Status: PROVISIONAL

    Source sequence(s)
    AB120005
    UniProtKB/TrEMBL
    Q75Y03
    Conserved Domains (4) summary
    cd01816
    Location:2495
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:103148
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14150
    Location:311575
    STKc_A-Raf; Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00069
    Location:315566
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    26853069..26869389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171817.4XP_005171874.1  serine/threonine-protein kinase A-Raf isoform X1

    See identical proteins and their annotated locations for XP_005171874.1

    UniProtKB/TrEMBL
    Q5FBD1
    Related
    ENSDARP00000118602.1, ENSDART00000138182.3
    Conserved Domains (4) summary
    cd01816
    Location:2495
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:103148
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14150
    Location:311575
    STKc_A-Raf; Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00069
    Location:315566
    Pkinase; Protein kinase domain
  2. XM_005171818.4XP_005171875.1  serine/threonine-protein kinase A-Raf isoform X2

    See identical proteins and their annotated locations for XP_005171875.1

    UniProtKB/TrEMBL
    Q5M7Y2
    Related
    ENSDARP00000118701.1, ENSDART00000140081.2
    Conserved Domains (4) summary
    cd01816
    Location:2495
    Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
    cd00029
    Location:103148
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14150
    Location:307571
    STKc_A-Raf; Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    pfam00069
    Location:311562
    Pkinase; Protein kinase domain
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