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map2k4a mitogen-activated protein kinase kinase 4a [ Danio rerio (zebrafish) ]

Gene ID: 403052, updated on 22-Aug-2021

Summary

Official Symbol
map2k4aprovided by ZNC
Official Full Name
mitogen-activated protein kinase kinase 4aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060512-98
See related
Ensembl:ENSDARG00000063583
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MKK4; map2; map2k4; MKK4A-l; zgc:136500
Orthologs
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Genomic context

See map2k4a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (10592597..10634531, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (10626051..10667999, complement)
103 previous assembly Zv9 (GCF_000002035.4) 3 NC_007114.5 (11494079..11536005, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 100a Neighboring gene elaC ribonuclease Z 2 Neighboring gene uncharacterized LOC110438746 Neighboring gene transmembrane protein 220

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC136500

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within determination of dorsal identity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4a
Names
mitogen-activated protein kinase kinase 4
mkk4a
NP_991299.2
XP_005164412.1
XP_009297453.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205736.2NP_991299.2  dual specificity mitogen-activated protein kinase kinase 4a

    See identical proteins and their annotated locations for NP_991299.2

    Status: PROVISIONAL

    Source sequence(s)
    EF433293
    UniProtKB/TrEMBL
    B1NA68
    Related
    ENSDARP00000106153.1, ENSDART00000130761.4
    Conserved Domains (2) summary
    smart00220
    Location:108372
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:101390
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    10592597..10634531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164355.4XP_005164412.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:93357
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:86375
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
  2. XM_009299178.3XP_009297453.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:97361
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:90379
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
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