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egf epidermal growth factor [ Danio rerio (zebrafish) ]

Gene ID: 403045, updated on 9-Sep-2025
Official Symbol
egfprovided by ZNC
Official Full Name
epidermal growth factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070922-1
See related
Ensembl:ENSDARG00000052739 AllianceGenome:ZFIN:ZDB-GENE-070922-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:eu639
Summary
Predicted to enable calcium ion binding activity and growth factor activity. Acts upstream of or within blood circulation and cartilage development. Predicted to be located in membrane. Is expressed in several structures, including central nervous system; notochord; opercular flap; pleuroperitoneal region; and scale. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See egf in Genome Data Viewer
Location:
chromosome: 14
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 14 NC_133189.1 (40896047..40944026, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 14 NC_007125.7 (36277204..36326050, complement)

Chromosome 14 - NC_133189.1Genomic Context describing neighboring genes Neighboring gene paired-like homeodomain 2 Neighboring gene ELOVL fatty acid elongase 6 Neighboring gene info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a Neighboring gene glycoprotein M6Aa

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Membrane interaction of bound ligands contributes to the negative binding cooperativity of the EGF receptor. Arkhipov A, et al. PLoS Comput Biol, 2014 Jul. PMID 25058506, Free PMC Article
  2. A Small Change With a Twist Ending: A Single Residue in EGF-CFC Drives Bilaterian Asymmetry. Truchado-García M, et al. Mol Biol Evol, 2023 Feb 3. PMID 36537201, Free PMC Article
  3. In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss. Vijayakumar S, et al. Sci Adv, 2024 Jun 21. PMID 38896614, Free PMC Article
  4. Developmental defects in zebrafish for classification of EGF pathway inhibitors. Pruvot B, et al. Toxicol Appl Pharmacol, 2014 Jan 15. PMID 24262764
  5. Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivo. Wolman MA, et al. Neural Dev, 2008 Feb 20. PMID 18289389, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Small Change With a Twist Ending: A Single Residue in EGF-CFC Drives Bilaterian Asymmetry.
    Title: A Small Change With a Twist Ending: A Single Residue in EGF-CFC Drives Bilaterian Asymmetry.
  2. Zebrafish scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis
    Title: Zebrafish scube1 (signal peptide-CUB (complement protein C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor) domain-containing protein 1) is involved in primitive hematopoiesis.
  3. These results suggest that there is an EGF signaling network in the zebrafish ovarian follicle, and the functionality of this network is self-regulated by its own members.
    Title: Differential regulation of betacellulin and heparin-binding EGF-like growth factor in cultured zebrafish ovarian follicle cells by EGF family ligands.
  4. EGF is likely a potential paracrine/juxtacrine factor from the oocytes to regulate the function of the follicle cells.
    Title: Cloning of epidermal growth factor (EGF) and EGF receptor from the zebrafish ovary: evidence for EGF as a potential paracrine factor from the oocyte to regulate activin/follistatin system in the follicle cells.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood circulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
pro-epidermal growth factor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365527.1 → NP_001352456.1  pro-epidermal growth factor isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    BX510944
    UniProtKB/TrEMBL
    A0AB13A7B8, Q6VQA2
    Related
    ENSDARP00000069126.5, ENSDART00000074639.7
    Conserved Domains (7) summary
    smart00135
    Location:634 → 676
    LY; Low-density lipoprotein-receptor YWTD domain
    cd05819
    Location:81 → 121
    NHL; NHL repeat [structural motif]
    cl18310
    Location:34 → 197
    NHL; NHL repeat unit of beta-propeller proteins
    pfam12947
    Location:907 → 942
    EGF_3; EGF domain
    pfam14670
    Location:441 → 476
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:351 → 394
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl28647
    Location:959 → 1058
    PHA02887; EGF-like protein; Provisional

  2. NM_001365528.1 → NP_001352457.1  pro-epidermal growth factor isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    BX510944
    UniProtKB/TrEMBL
    A0AB13A9F5, Q6VQA2
    Related
    ENSDARP00000142359.1, ENSDART00000172783.2
    Conserved Domains (6) summary
    smart00135
    Location:634 → 676
    LY; Low-density lipoprotein-receptor YWTD domain
    pfam12947
    Location:907 → 942
    EGF_3; EGF domain
    pfam14670
    Location:441 → 476
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:351 → 394
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl26742
    Location:36 → 159
    SGL; SMP-30/Gluconolaconase/LRE-like region
    cl28647
    Location:958 → 1057
    PHA02887; EGF-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133189.1 Reference GRCz12tu Primary Assembly

    Range
    40896047..40944026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073921303.1 → XP_073777404.1  pro-epidermal growth factor isoform X2

    UniProtKB/TrEMBL
    Q6VQA2

  2. XM_073921302.1 → XP_073777403.1  pro-epidermal growth factor isoform X1

    UniProtKB/TrEMBL
    Q6VQA2

  3. XM_073921304.1 → XP_073777405.1  pro-epidermal growth factor isoform X3

    UniProtKB/TrEMBL
    Q6VQA2

  4. XM_073921305.1 → XP_073777406.1  pro-epidermal growth factor isoform X4

    UniProtKB/TrEMBL
    Q6VQA2

  5. XM_073921307.1 → XP_073777408.1  pro-epidermal growth factor isoform X6

    UniProtKB/TrEMBL
    Q6VQA2

  6. XM_073921306.1 → XP_073777407.1  pro-epidermal growth factor isoform X5

    UniProtKB/TrEMBL
    Q6VQA2

RNA

  1. XR_012389430.1 RNA Sequence

  2. XR_012389429.1 RNA Sequence

  3. XR_012389428.1 RNA Sequence

  4. XR_012389423.1 RNA Sequence

  5. XR_012389422.1 RNA Sequence

  6. XR_012389431.1 RNA Sequence

  7. XR_012389424.1 RNA Sequence

  8. XR_012389425.1 RNA Sequence

  9. XR_012389426.1 RNA Sequence

  10. XR_012389432.1 RNA Sequence

  11. XR_012389433.1 RNA Sequence

  12. XR_012389427.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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