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pdpk1b 3-phosphoinositide dependent protein kinase 1b [ Danio rerio (zebrafish) ]

Gene ID: 403000, updated on 2-Nov-2024

Summary

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Official Symbol
pdpk1bprovided by ZNC
Official Full Name
3-phosphoinositide dependent protein kinase 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1820
See related
Ensembl:ENSDARG00000018285 AllianceGenome:ZFIN:ZDB-GENE-040426-1820
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77318
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See pdpk1b in Genome Data Viewer
Location:
chromosome: 24
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (37301852..37326125, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (37414132..37438405, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2Ib Neighboring gene potassium channel tetramerization domain containing 5b Neighboring gene TSR3 ribosome maturation factor Neighboring gene N-acetylglucosamine-1-phosphate transferase subunit gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC77318

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3-phosphoinositide-dependent protein kinase 1
NP_991262.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205699.1 → NP_991262.1  3-phosphoinositide-dependent protein kinase 1

    See identical proteins and their annotated locations for NP_991262.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065959
    UniProtKB/TrEMBL
    A0A8M1PGP9, Q6NZV1
    Related
    ENSDARP00000019085.7, ENSDART00000003789.8
    Conserved Domains (3) summary
    smart00220
    Location:60 → 320
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01262
    Location:423 → 529
    PH_PDK1; 3-Phosphoinositide dependent protein kinase 1 (PDK1) pleckstrin homology (PH) domain
    cd05581
    Location:58 → 320
    STKc_PDK1; Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    37301852..37326125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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