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ARL3 ADP ribosylation factor like GTPase 3 [ Homo sapiens (human) ]

Gene ID: 403, updated on 7-Dec-2018

Summary

Official Symbol
ARL3provided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 3provided by HGNC
Primary source
HGNC:HGNC:694
See related
Ensembl:ENSG00000138175 MIM:604695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RP83; ARFL3; JBTS35
Summary
ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 13.2), kidney (RPKM 7.9) and 24 other tissues See more
Orthologs

Genomic context

See ARL3 in Genome Data Viewer
Location:
10q24.32
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (102673727..102714433, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104433484..104474190, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene RNA, U6 small nuclear 43, pseudogene Neighboring gene uncharacterized LOC105378460 Neighboring gene tripartite motif containing 8 Neighboring gene sideroflexin 2 Neighboring gene WW domain binding protein 1 like Neighboring gene RNA, U6 small nuclear 1231, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cargo trafficking to the periciliary membrane, organism-specific biosystem (from REACTOME)
    Cargo trafficking to the periciliary membrane, organism-specific biosystemProteomic studies suggest that the cilium is home to approximately a thousand proteins, and has a unique protein and lipid make up relative to the bulk cytoplasm and plasma membrane (Pazour et al, 20...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Trafficking of myristoylated proteins to the cilium, organism-specific biosystem (from REACTOME)
    Trafficking of myristoylated proteins to the cilium, organism-specific biosystemA number of myristoylated proteins have been shown to traffic to the cilium in a myristoyl- and UNC119B:ARL3:RP2-dependent fashion. These include the ciliary proteins Nephrocystin 3 (NPHP3) and Cyst...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activating protein binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to plasma membrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
intraciliary transport IEA
Inferred from Electronic Annotation
more info
 
kidney development ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
photoreceptor cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
post-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
small GTPase mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
NOT cilium IDA
Inferred from Direct Assay
more info
PubMed 
cilium TAS
Traceable Author Statement
more info
 
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
PubMed 
spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 3
Names
ADP-ribosylation factor-like 3
ARF-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004311.4NP_004302.1  ADP-ribosylation factor-like protein 3

    See identical proteins and their annotated locations for NP_004302.1

    Status: REVIEWED

    Source sequence(s)
    AL391121
    Consensus CDS
    CCDS7538.1
    UniProtKB/Swiss-Prot
    P36405
    Related
    ENSP00000260746.4, ENST00000260746.5
    Conserved Domains (1) summary
    cd04155
    Location:3176
    Arl3; Arf-like 3 (Arl3) GTPase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    102673727..102714433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016260.1XP_016871749.1  ADP-ribosylation factor-like protein 3 isoform X1

    UniProtKB/Swiss-Prot
    P36405
    Conserved Domains (1) summary
    cd04155
    Location:3176
    Arl3; Arf-like 3 (Arl3) GTPase
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