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rcor2 REST corepressor 2 [ Danio rerio (zebrafish) ]

Gene ID: 402934, updated on 9-Sep-2025
Official Symbol
rcor2provided by ZNC
Official Full Name
REST corepressor 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1812
See related
Ensembl:ENSDARG00000008278 AllianceGenome:ZFIN:ZDB-GENE-040426-1812
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77264
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in brain; pectoral fin; and ventral mesoderm. Orthologous to human RCOR2 (REST corepressor 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See rcor2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 7 NC_133182.1 (24965966..24981770, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 7 NC_007118.7 (24979833..24995613, complement)

Chromosome 7 - NC_133182.1Genomic Context describing neighboring genes Neighboring gene kelch repeat-containing protein Neighboring gene uncharacterized LOC141375363 Neighboring gene MAP/microtubule affinity-regulating kinase 2b Neighboring gene N-alpha-acetyltransferase 40, NatD catalytic subunit Neighboring gene beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. CoRest1 regulates neurogenesis in a stage-dependent manner. Monestime CM, et al. Dev Dyn, 2019 Oct. PMID 31301200, Free PMC Article
  2. Zebrafish rest regulates developmental gene expression but not neurogenesis. Kok FO, et al. Development, 2012 Oct. PMID 22951640, Free PMC Article
  3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC77264

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
REST corepressor 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205638.1 → NP_991201.1  REST corepressor 2

    See identical proteins and their annotated locations for NP_991201.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065331
    UniProtKB/Swiss-Prot
    Q6P116
    Related
    ENSDARP00000026854.5, ENSDART00000002961.7
    Conserved Domains (4) summary
    smart00717
    Location:332 → 377
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:332 → 375
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:40 → 92
    ELM2; ELM2 domain
    cl21498
    Location:128 → 172
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133182.1 Reference GRCz12tu Primary Assembly

    Range
    24965966..24981770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005172265.6 → XP_005172322.1  REST corepressor 2 isoform X2

    See identical proteins and their annotated locations for XP_005172322.1

    UniProtKB/TrEMBL
    A0A8M2BJM6
    Conserved Domains (4) summary
    smart00717
    Location:294 → 339
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:294 → 337
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:2 → 54
    ELM2; ELM2 domain
    cl21498
    Location:90 → 134
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. XM_005172263.6 → XP_005172320.1  REST corepressor 2 isoform X1

    See identical proteins and their annotated locations for XP_005172320.1

    UniProtKB/Swiss-Prot
    Q6P116
    Conserved Domains (4) summary
    smart00717
    Location:332 → 377
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:332 → 375
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:40 → 92
    ELM2; ELM2 domain
    cl21498
    Location:128 → 172
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  3. XM_005172264.5 → XP_005172321.1  REST corepressor 2 isoform X2

    See identical proteins and their annotated locations for XP_005172321.1

    UniProtKB/TrEMBL
    A0A8M2BJM6
    Conserved Domains (4) summary
    smart00717
    Location:294 → 339
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:294 → 337
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam01448
    Location:2 → 54
    ELM2; ELM2 domain
    cl21498
    Location:90 → 134
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  4. XM_073906360.1 → XP_073762461.1  REST corepressor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P116

  5. XM_073906361.1 → XP_073762462.1  REST corepressor 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P116.1 GenPept UniProtKB/Swiss-Prot:Q6P116

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