lhcgr luteinizing hormone/choriogonadotropin receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lhcgrprovided by ZNC
Official Full Name: luteinizing hormone/choriogonadotropin receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040806-3
See related: Ensembl:ENSDARG00000026081 AllianceGenome:ZFIN:ZDB-GENE-040806-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lhr; GTHR-II; zfGTHR-II
Summary: Enables luteinizing hormone receptor activity. Acts upstream of or within gamete generation and gonad development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in digestive system; female organism; gonad; and hypophysis. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (47573473..47618843)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (47283648..47329018)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that double mutation of follicle-stimulating hormone receptor (fshr) and luteinizing hormone receptor (lhcgr) resulted in infertile males
Title: Disruption of Zebrafish Follicle-Stimulating Hormone Receptor (fshr) But Not Luteinizing Hormone Receptor (lhcgr) Gene by TALEN Leads to Failed Follicle Activation in Females Followed by Sexual Reversal to Males.
Data show for the first time in a vertebrate species that Leydig cells as well as Sertoli cells express the mRNAs for both fshr and lhcgr.
Title: Studies in zebrafish reveal unusual cellular expression patterns of gonadotropin receptor messenger ribonucleic acids in the testis and unexpected functional differentiation of the gonadotropins.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables luteinizing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables luteinizing hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables luteinizing hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables thyroid-stimulating hormone receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in luteinizing hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gonad development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian follicle development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation cycle process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lutropin-choriogonadotropic hormone receptor

Names: luteinizing hormone receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205625.1 → NP_991188.1 lutropin-choriogonadotropic hormone receptor precursor

See identical proteins and their annotated locations for NP_991188.1

Status: PROVISIONAL

Source sequence(s)

AY424302

UniProtKB/TrEMBL

Q6TCF8

Related

ENSDARP00000088230.3, ENSDART00000097459.4

Conserved Domains (4) summary

sd00033
Location:47 → 70

LRR_RI; leucine-rich repeat [structural motif]

pfam00001
Location:386 → 633

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam12369
Location:283 → 356

GnHR_trans; Gonadotropin hormone receptor transmembrane region

pfam13306
Location:58 → 216

LRR_5; Leucine rich repeats (6 copies)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

47573473..47618843

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021480550.1 → XP_021336225.1 lutropin-choriogonadotropic hormone receptor isoform X1

UniProtKB/TrEMBL

A0A8M9QNC1

Conserved Domains (4) summary

sd00033
Location:46 → 70

LRR_RI; leucine-rich repeat [structural motif]

pfam12369
Location:258 → 331

GnHR_trans; Gonadotropin hormone receptor transmembrane region

cd15136
Location:345 → 618

7tmA_Glyco_hormone_R; glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

cl26222
Location:33 → 191

LRR_5; Leucine rich repeats (6 copies)