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LPP LIM domain containing preferred translocation partner in lipoma [ Homo sapiens (human) ]

Gene ID: 4026, updated on 1-Jun-2020

Summary

Official Symbol
LPPprovided by HGNC
Official Full Name
LIM domain containing preferred translocation partner in lipomaprovided by HGNC
Primary source
HGNC:HGNC:6679
See related
Ensembl:ENSG00000145012 MIM:600700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in endometrium (RPKM 14.7), esophagus (RPKM 14.3) and 24 other tissues See more
Orthologs

Genomic context

See LPP in Genome Data Viewer
Location:
3q27.3-q28
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (188152152..188890671)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (187871097..188608460)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2895 Neighboring gene uncharacterized LOC107986166 Neighboring gene LPP antisense RNA 2 Neighboring gene uncharacterized LOC401105 Neighboring gene Sharpr-MPRA regulatory region 910 Neighboring gene LPP antisense RNA 1 Neighboring gene microRNA 28 Neighboring gene uncharacterized LOC107986168 Neighboring gene TPRG1 antisense RNA 1 Neighboring gene enolase-phosphatase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Acute myeloid leukemia Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
NHGRI GWA Catalog
Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
NHGRI GWA Catalog
Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese.
NHGRI GWA Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region.
NHGRI GWA Catalog
Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.
NHGRI GWA Catalog
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog
Newly identified genetic risk variants for celiac disease related to the immune response.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
NHGRI GWA Catalog
White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of LIM domain containing preferred translocation partner in lipoma (LPP) by siRNA enhances HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30652, FLJ41512, DKFZp779O0231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
focal adhesion HDA PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
lipoma-preferred partner
Names
LIM protein
lipoma preferred partner

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016932.2 RefSeqGene

    Range
    5024..741797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001167671.3NP_001161143.1  lipoma-preferred partner isoform a

    See identical proteins and their annotated locations for NP_001161143.1

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228
    Consensus CDS
    CCDS3291.1
    UniProtKB/Swiss-Prot
    Q93052
    UniProtKB/TrEMBL
    B7ZLW0
    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family
  2. NM_001167672.3NP_001161144.1  lipoma-preferred partner isoform b

    See identical proteins and their annotated locations for NP_001161144.1

    Status: REVIEWED

    Source sequence(s)
    AC009319, AI126032, AK304035, AW301088, CD697098, KF510228
    UniProtKB/TrEMBL
    B7Z8W0
    Conserved Domains (3) summary
    cd09350
    Location:269322
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:329381
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl02475
    Location:389454
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. NM_001375455.1NP_001362384.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228
  4. NM_001375456.1NP_001362385.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, KF510228
  5. NM_001375457.1NP_001362386.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228
  6. NM_001375458.1NP_001362387.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228
  7. NM_001375459.1NP_001362388.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228
  8. NM_001375460.1NP_001362389.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228
  9. NM_001375461.1NP_001362390.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, KF510228
  10. NM_001375462.1NP_001362391.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228
    Related
    ENSP00000478901.1, ENST00000617246.4
  11. NM_001375463.1NP_001362392.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228
  12. NM_001375464.1NP_001362393.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228
  13. NM_001375465.1NP_001362394.1  lipoma-preferred partner isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, KF510228
  14. NM_005578.5NP_005569.1  lipoma-preferred partner isoform a

    See identical proteins and their annotated locations for NP_005569.1

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228
    Consensus CDS
    CCDS3291.1
    UniProtKB/Swiss-Prot
    Q93052
    Related
    ENSP00000491657.1, ENST00000640853.1
    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family

RNA

  1. NR_164692.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009319, AC022498, AC055711, AC063932, AC069226, AC117507, KF510228

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    188152152..188890671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453519.1XP_024309287.1  lipoma-preferred partner isoform X2

    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family
  2. XM_017006379.2XP_016861868.1  lipoma-preferred partner isoform X2

    UniProtKB/Swiss-Prot
    Q93052
    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family
  3. XM_011512820.3XP_011511122.1  lipoma-preferred partner isoform X2

    See identical proteins and their annotated locations for XP_011511122.1

    UniProtKB/Swiss-Prot
    Q93052
    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family
  4. XM_011512828.3XP_011511130.1  lipoma-preferred partner isoform X2

    See identical proteins and their annotated locations for XP_011511130.1

    UniProtKB/Swiss-Prot
    Q93052
    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family
  5. XM_017006380.2XP_016861869.1  lipoma-preferred partner isoform X2

    UniProtKB/Swiss-Prot
    Q93052
    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family
  6. XM_005247450.5XP_005247507.1  lipoma-preferred partner isoform X2

    See identical proteins and their annotated locations for XP_005247507.1

    UniProtKB/Swiss-Prot
    Q93052
    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family
  7. XM_011512831.3XP_011511133.1  lipoma-preferred partner isoform X2

    See identical proteins and their annotated locations for XP_011511133.1

    UniProtKB/Swiss-Prot
    Q93052
    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family
  8. XM_017006377.1XP_016861866.1  lipoma-preferred partner isoform X2

    UniProtKB/Swiss-Prot
    Q93052
    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family
  9. XM_017006378.1XP_016861867.1  lipoma-preferred partner isoform X2

    UniProtKB/Swiss-Prot
    Q93052
    Conserved Domains (4) summary
    cd09350
    Location:416469
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:476528
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:536601
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl26464
    Location:19388
    Atrophin-1; Atrophin-1 family
  10. XM_017006381.1XP_016861870.1  lipoma-preferred partner isoform X3

    Related
    ENSP00000393602.1, ENST00000448637.5
    Conserved Domains (2) summary
    PRK14086
    Location:191380
    dnaA; chromosomal replication initiation protein; Provisional
    PRK14971
    Location:141219
    PRK14971; DNA polymerase III subunits gamma and tau; Provisional
  11. XM_011512823.2XP_011511125.1  lipoma-preferred partner isoform X1

    Conserved Domains (4) summary
    cd09350
    Location:441494
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:501553
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09436
    Location:561626
    LIM3_TRIP6; The third LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl23807
    Location:229316
    WWbp; WW-domain ligand protein
  12. XM_017006382.1XP_016861871.1  lipoma-preferred partner isoform X4

    UniProtKB/TrEMBL
    B7Z871
    Conserved Domains (4) summary
    cd09350
    Location:253306
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:313365
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl02475
    Location:373438
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl23807
    Location:41128
    WWbp; WW-domain ligand protein
  13. XM_011512836.3XP_011511138.1  lipoma-preferred partner isoform X4

    See identical proteins and their annotated locations for XP_011511138.1

    UniProtKB/TrEMBL
    B7Z871
    Conserved Domains (4) summary
    cd09350
    Location:253306
    LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cd09356
    Location:313365
    LIM2_TRIP6; The second LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
    cl02475
    Location:373438
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl23807
    Location:41128
    WWbp; WW-domain ligand protein

RNA

  1. XR_001740144.1 RNA Sequence

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