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Toll-9 Toll-9 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40245, updated on 8-Apr-2026
Official Symbol
Toll-9provided by FlyBase
Official Full Name
Toll-9provided by FlyBase
Primary source
FLYBASE:FBgn0036978
Locus tag
Dmel_CG5528
See related
AllianceGenome:FB:FBgn0036978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5528; CT17508; Dm Toll-9; Dmel\CG5528; dTLR9; dToll9; Tak/Toll-like; Tl-5; Tl-9; toll; Toll; Toll 9; TOLL 9; Toll-6; Toll9
Summary
Predicted to enable signaling receptor activity. Involved in signal transduction. Predicted to be active in plasma membrane. Is expressed in embryonic hemocyte anlage and yolk nucleus. Human ortholog(s) of this gene implicated in several diseases, including dermatitis (multiple); liver disease (multiple); primary immunodeficiency disease (multiple); rhinitis (multiple); and tuberculosis (multiple). Orthologous to several human genes including TLR10 (toll like receptor 10). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Toll-9 in Genome Data Viewer
Location:
77B6-77B6; 3-47 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20361843..20366724, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20354943..20359824, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA primase subunit 2 Neighboring gene inturned Neighboring gene uncharacterized protein Neighboring gene Insulin degrading metalloproteinase

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration. Sakakibara Y, et al. iScience, 2023 Feb 17. PMID 36718365, Free PMC Article
  2. Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila. Levin TC, et al. Mol Biol Evol, 2017 Sep 1. PMID 28541576, Free PMC Article
  3. The chromosomes of Drosophila suzukii (Diptera: Drosophilidae): detailed photographic polytene chromosomal maps and in situ hybridization data. Drosopoulou E, et al. Mol Genet Genomics, 2019 Dec. PMID 31346719
  4. Lack of an antibacterial response defect in Drosophila Toll-9 mutant. Narbonne-Reveau K, et al. PLoS One, 2011 Feb 28. PMID 21386906, Free PMC Article
  5. The Role of Toll and Nonnuclear NF-κB Signaling in the Response to Alcohol. Atkinson NS. Cells, 2023 May 30. PMID 37296629, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Toll-9
Names
CG5528-PA
CG5528-PB
CG5528-PC
Toll-9-PA
Toll-9-PB
Toll-9-PC
toll receptor

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20361843..20366724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140957.4 → NP_649214.1  Toll-9, isoform A

    See identical proteins and their annotated locations for NP_649214.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6IDT6, Q9VPH1
    Related
    FBpp0077898
    Conserved Domains (4) summary
    smart00255
    Location:751 → 891
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:449 → 536
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:288 → 311
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:477 → 536
    LRR_8; Leucine rich repeat

  2. NM_001259916.2 → NP_001246845.1  Toll-9, isoform B

    See identical proteins and their annotated locations for NP_001246845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6IDT6, M9NDW9
    Conserved Domains (5) summary
    smart00255
    Location:677 → 817
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:375 → 462
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:358 → 372
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:157 → 189
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:403 → 462
    LRR_8; Leucine rich repeat

  3. NM_001259917.1 → NP_001246846.1  Toll-9, isoform C

    See identical proteins and their annotated locations for NP_001246846.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6IDT6, Q9VPH1
    Conserved Domains (4) summary
    smart00255
    Location:751 → 891
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:449 → 536
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:288 → 311
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:477 → 536
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDW9 M9NDW9
Q9VPH1 Q9VPH1

Gene LinkOut

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