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SRRD SRR1 domain containing [ Homo sapiens (human) ]

Gene ID: 402055, updated on 5-Aug-2022

Summary

Official Symbol
SRRDprovided by HGNC
Official Full Name
SRR1 domain containingprovided by HGNC
Primary source
HGNC:HGNC:33910
See related
Ensembl:ENSG00000100104 MIM:602254; AllianceGenome:HGNC:33910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRR1L; HC/HCC
Summary
Predicted to be involved in microtubule-based process; regulation of circadian rhythm; and regulation of heme biosynthetic process. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 8.9), testis (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

See SRRD in Genome Data Viewer
Location:
22q12.1
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (26483877..26494658)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (26946287..26957060)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (26879843..26890624)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S3A pseudogene Neighboring gene aspartate beta-hydroxylase domain containing 2 Neighboring gene HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 Neighboring gene tuftelin interacting protein 11 Neighboring gene TFIP11 divergent transcript Neighboring gene tyrosylprotein sulfotransferase 2 Neighboring gene microRNA 548j

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of heme biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
SRR1-like protein
Names
SRR1 domain-containing protein
hepatocellular carcinoma complicating hemochromatosis

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013694.3NP_001013716.2  SRR1-like protein

    See identical proteins and their annotated locations for NP_001013716.2

    Status: VALIDATED

    Source sequence(s)
    BC066962, BQ189353, DA325985, KF457388, Z99714
    Consensus CDS
    CCDS42995.1
    UniProtKB/Swiss-Prot
    Q6NXP8, Q9UH36
    Related
    ENSP00000215917.6, ENST00000215917.11
    Conserved Domains (1) summary
    cl06844
    Location:139298
    SRR1; SRR1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    26483877..26494658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530178.3XP_011528480.1  SRR1-like protein isoform X1

    Conserved Domains (1) summary
    cl06844
    Location:68227
    SRR1; SRR1
  2. XM_017028799.3XP_016884288.1  SRR1-like protein isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    26946287..26957060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)