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RNF223 ring finger protein 223 [ Homo sapiens (human) ]

Gene ID: 401934, updated on 25-Jan-2022

Summary

Official Symbol
RNF223provided by HGNC
Official Full Name
ring finger protein 223provided by HGNC
Primary source
HGNC:HGNC:40020
See related
Ensembl:ENSG00000237330 AllianceGenome:HGNC:40020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable metal ion binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in esophagus (RPKM 1.5), stomach (RPKM 1.1) and 19 other tissues See more
Orthologs
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Genomic context

See RNF223 in Genome Data Viewer
Location:
1p36.33
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (1070967..1074306, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1006347..1009686, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100288175 Neighboring gene uncharacterized LOC105378948 Neighboring gene conserved acetylation island sequence 30 enhancer Neighboring gene chromosome 1 open reading frame 159 Neighboring gene Sharpr-MPRA regulatory region 13538 Neighboring gene CRISPRi-validated cis-regulatory element chr1.97

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205252.2NP_001192181.1  RING finger protein 223

    See identical proteins and their annotated locations for NP_001192181.1

    Status: VALIDATED

    Source sequence(s)
    AK296576, AL390719
    Consensus CDS
    CCDS53257.1
    UniProtKB/Swiss-Prot
    E7ERA6
    Related
    ENSP00000410533.1, ENST00000453464.3
    Conserved Domains (1) summary
    cd00162
    Location:50105
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    1070967..1074306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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