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CG7668 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40190, updated on 7-Apr-2025

Summary

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Official Symbol
CG7668provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036929
Locus tag
Dmel_CG7668
See related
AllianceGenome:FB:FBgn0036929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF49079; AAM11109; AAN11645; BcDNA:GM07843; BcDNA:RE40293; Dmel\CG7668; FBpp0074673; FBpp0074674
Summary
Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in cardiovascular system disease (multiple); congenital afibrinogenemia; and end stage renal disease. Orthologous to human FGB (fibrinogen beta chain) and TNN (tenascin N). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
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Genomic context

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See CG7668 in Genome Data Viewer
Location:
76E1-76E1; 3-46 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20002736..20004834)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19995836..19997934)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neurocalcin Neighboring gene gamma-aminobutyric acid transaminase Neighboring gene Translocase of outer membrane 20 Neighboring gene kugelei Neighboring gene uncharacterized protein Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterization of the fibrinogen-like domain of fibrinogen-related proteins in the mosquito, Anopheles gambiae, and the fruitfly, Drosophila melanogaster, genomes. Wang X, et al. BMC Genomics, 2005 Sep 8. PMID 16150145, Free PMC Article
  2. Evolution and potential function of fibrinogen-like domains across twelve Drosophila species. Middha S, et al. BMC Genomics, 2008 May 30. PMID 18513432, Free PMC Article
  3. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Zdobnov EM, et al. Science, 2002 Oct 4. PMID 12364792
  4. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article
  5. Insect response to alphavirus infection--establishment of alphavirus persistence in insect cells involves inhibition of viral polyprotein cleavage. Mudiganti U, et al. Virus Res, 2010 Jun. PMID 20214937

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7668-PA
CG7668-PC
Fibrinogen-related protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20002736..20004834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168830.2 → NP_730478.2  uncharacterized protein Dmel_CG7668, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730478.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQU9, Q8SYR0, Q9VW70
    Conserved Domains (2) summary
    pfam01519
    Location:146 → 212
    DUF16; Protein of unknown function DUF16
    cl00085
    Location:245 → 421
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

  2. NM_140913.2 → NP_649170.1  uncharacterized protein Dmel_CG7668, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649170.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQU9, Q8SYR0, Q9VW70
    Related
    FBpp0074673
    Conserved Domains (2) summary
    pfam01519
    Location:146 → 212
    DUF16; Protein of unknown function DUF16
    cl00085
    Location:245 → 421
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SYR0 Q8SYR0
Q8T3M7 Q8T3M7
Q9VW70 Q9VW70

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