fln flightin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: flnprovided by FlyBase
Official Full Name: flightinprovided by FlyBase
Primary source: FLYBASE:FBgn0005633
Locus tag: Dmel_CG7445
See related: AllianceGenome:FB:FBgn0005633
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7445; Dmel\CG7445; Fln; Ftn; mp27
Summary: Enables structural molecule activity conferring elasticity. A structural constituent of muscle. Involved in adult somatic muscle development; myofibril assembly; and oscillatory muscle contraction. Located in A band and striated muscle myosin thick filament. Is expressed in adult head; adult heart; and indirect flight muscle cell. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: 76D8-76D8; 3-46 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19989551..19991220, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19982651..19984320, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

phosphorylation of D. melanogaster flightin is modulated during flight
Title: Intrinsic disorder and multiple phosphorylations constrain the evolution of the flightin N-terminal region.
COOH terminus of flightin is necessary for normal myofilament lattice organization, thereby facilitating the cross-bridge binding required to achieve high power output for flight.
Title: COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle.
used atomic force microscopy to study the morphological and mechanical properties of fully hydrated native thick filaments isolated from indirect flight muscle of normal and mutants lacking flightin
Title: Flightin is necessary for length determination, structural integrity, and large bending stiffness of insect flight muscle thick filaments.
Results illustrate the importance of flightin in flight muscle development and function.
Title: Flight muscle properties and aerodynamic performance of Drosophila expressing a flightin transgene.
Flightin is a major contributor to myofilament stiffness and a key determinant of the enhanced delayed force response to stretch in Drosophila flight muscles.
Title: Mutations that affect flightin expression in Drosophila alter the viscoelastic properties of flight muscle fibers.
Myofilin is probably needed for filament assembly in all muscles, and flightin for stability of flight muscle thick filaments in adult flies
Title: Myofilin, a protein in the thick filaments of insect muscle.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables structural constituent of muscle	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural molecule activity conferring elasticity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adult somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oscillatory muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striated muscle myosin thick filament assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in striated muscle myosin thick filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
located_in striated muscle myosin thick filament	HDA more info	PubMed
located_in striated muscle myosin thick filament	IDA Inferred from Direct Assay more info	PubMed