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Mi-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40170, updated on 22-May-2022

Summary

Official Symbol
Mi-2provided by FlyBase
Primary source
FLYBASE:FBgn0262519
Locus tag
Dmel_CG8103
See related
AllianceGenome:FB:FBgn0262519
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0006/06; 0854/01; CG8103; Chd4; Dm-Mi-2; Dmel\CG8103; dMi; dMi-2; dMI-2; dMi2; hip76; l(3)01058; l(3)76BDe; l(3)A154.3M3; l(3)j3D4; l(3)L1243; l(3)S000606; l(3)S085401; M-i2; Mi 2; MI-2; Mi2; MI2; pha; Pha
Summary
Enables several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and nucleosome binding activity. Involved in several processes, including chromosome organization; negative regulation of cohesin loading; and negative regulation of transcription by RNA polymerase II. Located in nucleus; polytene chromosome; and transcriptionally active chromatin. Is expressed in several structures, including embryonic/larval digestive system; embryonic/larval fat body; germline cell; head; and wing disc. Orthologous to several human genes including CHD3 (chromodomain helicase DNA binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Mi-2 in Genome Data Viewer
Location:
76D3-76D4; 3-46 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19882051..19910215, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19875151..19903315, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Rab8 Neighboring gene Ubiquitin specific protease 32 Neighboring gene Su(Tpl) Neighboring gene long non-coding RNA:CR32218 Neighboring gene antisense RNA:CR43889 Neighboring gene Precursor RNA processing 3 Neighboring gene Mtr3 Neighboring gene Regulatory particle non-ATPase 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP-dependent chromatin remodeler activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP-dependent chromatin remodeler activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
PubMed 
Component Evidence Code Pubs
part_of NuRD complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of NuRD complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol HDA PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Mi-2
Names
CG8103-PA
CG8103-PB
CG8103-PC
CG8103-PD
Mi-2 ortholog
Mi-2-PA
Mi-2-PB
Mi-2-PC
Mi-2-PD
PHD-containing ATPase
dMi-2
hb-interacting protein 76
lethal (3) L1243
NP_001014591.1
NP_001163476.1
NP_001262078.1
NP_649154.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19882051..19910215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140897.4NP_649154.2  Mi-2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649154.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O97159
    UniProtKB/TrEMBL
    E1JI46
    Related
    FBpp0074688, FBtr0074919
    Conserved Domains (11) summary
    smart00298
    Location:614666
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:489557
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:750906
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:379421
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:439481
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7331027
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10521166
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13791516
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12911336
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:137189
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17551926
    CHDCT2; CHDCT2 (NUC038) domain
  2. NM_001170005.2NP_001163476.1  Mi-2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163476.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O97159
    UniProtKB/TrEMBL
    E1JI46
    Related
    FBpp0291256, FBtr0302046
    Conserved Domains (11) summary
    smart00298
    Location:614666
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:489557
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:750906
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:379421
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:439481
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7331027
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10521166
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13791516
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12911336
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:137189
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17551926
    CHDCT2; CHDCT2 (NUC038) domain
  3. NM_001014591.3NP_001014591.1  Mi-2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014591.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59E34
    Related
    FBpp0099808, FBtr0100394
    Conserved Domains (11) summary
    smart00298
    Location:615667
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:490558
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:751907
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:380422
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:440482
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7341028
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10531167
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13801517
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12921337
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:138190
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17561927
    CHDCT2; CHDCT2 (NUC038) domain
  4. NM_001275149.1NP_001262078.1  Mi-2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262078.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PIA6
    Related
    FBpp0304462, FBtr0332152
    Conserved Domains (11) summary
    smart00298
    Location:605657
    CHROMO; Chromatin organization modifier domain
    cd00024
    Location:480548
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00046
    Location:741897
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd15531
    Location:370412
    PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    cd15532
    Location:430472
    PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
    pfam00176
    Location:7241018
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:10431157
    Helicase_C; Helicase conserved C-terminal domain
    pfam06461
    Location:13701507
    DUF1086; Domain of Unknown Function (DUF1086)
    pfam06465
    Location:12821327
    DUF1087; Domain of Unknown Function (DUF1087)
    pfam08073
    Location:128180
    CHDNT; CHDNT (NUC034) domain
    pfam08074
    Location:17461917
    CHDCT2; CHDCT2 (NUC038) domain