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cyc cycle [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40162, updated on 28-Aug-2019

Summary

Official Symbol
cycprovided by FlyBase
Official Full Name
cycleprovided by FlyBase
Primary source
FLYBASE:FBgn0023094
Locus tag
Dmel_CG8727
Gene type
protein coding
RNA name
cycle
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bHLHe7; bMAL1; Bmal1; BMAL1; CG8727; Cyc; CYC; Cycle; CYCLE; dBma1; dbmal; dBmal; dBMAL; dbmal1; dBMAL1; dCYC; Dmel\CG8727; Mop3; MOP3; TGO_CYC

Genomic context

See cyc in Genome Data Viewer
Location:
76C6-76C6; 3-46 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19813770..19815938, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19806870..19809038, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene karyopherin alpha1 Neighboring gene Cyp305a1 Neighboring gene fibp Neighboring gene Deformed epidermal autoregulatory factor-1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Circadian rhythm - fly, organism-specific biosystem (from KEGG)
    Circadian rhythm - fly, organism-specific biosystemCircadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In the fruit fly Drosophila melanogaster, seven genes ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase II regulatory region sequence-specific DNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
behavioral response to cocaine NAS
Non-traceable Author Statement
more info
PubMed 
behavioral response to cocaine TAS
Traceable Author Statement
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm NAS
Non-traceable Author Statement
more info
PubMed 
circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
eclosion rhythm NAS
Non-traceable Author Statement
more info
PubMed 
eclosion rhythm TAS
Traceable Author Statement
more info
PubMed 
locomotor rhythm NAS
Non-traceable Author Statement
more info
PubMed 
locomotor rhythm TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian sleep/wake cycle, sleep TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
rhythmic behavior TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cycle
Names
CG8727-PA
brain and muscle ARNT-like 1
cyc-PA

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19813770..19815938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079444.3NP_524168.2  cycle [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524168.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61734
    Related
    FBpp0074693, FBtr0074924
    Conserved Domains (5) summary
    smart00091
    Location:111173
    PAS; PAS domain
    cd00130
    Location:311406
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:3184
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:111212
    PAS; PAS fold
    pfam14598
    Location:311411
    PAS_11; PAS domain
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