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WDR38 WD repeat domain 38 [ Homo sapiens (human) ]

Gene ID: 401551, updated on 23-Nov-2021

Summary

Official Symbol
WDR38provided by HGNC
Official Full Name
WD repeat domain 38provided by HGNC
Primary source
HGNC:HGNC:23745
See related
Ensembl:ENSG00000136918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in lung (RPKM 2.9), testis (RPKM 2.5) and 7 other tissues See more
Orthologs
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Genomic context

See WDR38 in Genome Data Viewer
Location:
9q33.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (124853460..124857884)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127615739..127620157)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987126 Neighboring gene olfactomedin like 2A Neighboring gene ribosomal protein L35 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene golgin A1 Neighboring gene RNA, U4 small nuclear 82, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WD repeat-containing protein 38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045476.3NP_001038941.1  WD repeat-containing protein 38 isoform 2

    See identical proteins and their annotated locations for NP_001038941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.
    Source sequence(s)
    AA867995, AL354928, BC150645
    Consensus CDS
    CCDS43876.1
    UniProtKB/Swiss-Prot
    Q5JTN6
    UniProtKB/TrEMBL
    B9EK65
    Related
    ENSP00000362677.1, ENST00000373574.2
    Conserved Domains (3) summary
    COG2319
    Location:11298
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:20300
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2661
    7WD40; WD40 repeat [structural motif]
  2. NM_001276374.2NP_001263303.1  WD repeat-containing protein 38 isoform 1

    See identical proteins and their annotated locations for NP_001263303.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA867995, AL354928, BC171828, BC171830
    Consensus CDS
    CCDS75898.1
    UniProtKB/TrEMBL
    A0A087X0D8, B7ZW23, B7ZW24
    Related
    ENSP00000483312.1, ENST00000613760.4
    Conserved Domains (3) summary
    COG2319
    Location:11299
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:20301
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2661
    7WD40; WD40 repeat [structural motif]
  3. NM_001276375.2NP_001263304.1  WD repeat-containing protein 38 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AA867995, AL354928, BC171830
    UniProtKB/TrEMBL
    B7ZW24
    Conserved Domains (3) summary
    COG2319
    Location:17288
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:11290
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5692
    7WD40; WD40 repeat [structural motif]
  4. NM_001276376.2NP_001263305.1  WD repeat-containing protein 38 isoform 4

    See identical proteins and their annotated locations for NP_001263305.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) initiates translation at an alternate downstream start codon and has a distinct and shorter internal segment in the CDS, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA867995, AL354928, BC171837
    Consensus CDS
    CCDS75899.1
    UniProtKB/TrEMBL
    A0A087X0J1
    Related
    ENSP00000483432.1, ENST00000618744.4
    Conserved Domains (2) summary
    cd00200
    Location:54250
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:6096
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    124853460..124857884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251987.4XP_005252044.1  WD repeat-containing protein 38 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:11272
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:20274
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2661
    7WD40; WD40 repeat [structural motif]
  2. XM_024447545.1XP_024303313.1  WD repeat-containing protein 38 isoform X2

    Conserved Domains (2) summary
    cd00200
    Location:54250
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:6096
    7WD40; WD40 repeat [structural motif]
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