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HACD4 3-hydroxyacyl-CoA dehydratase 4 [ Homo sapiens (human) ]

Gene ID: 401494, updated on 18-Aug-2020

Summary

Official Symbol
HACD4provided by HGNC
Official Full Name
3-hydroxyacyl-CoA dehydratase 4provided by HGNC
Primary source
HGNC:HGNC:20920
See related
Ensembl:ENSG00000188921 MIM:615941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPLAD2
Expression
Broad expression in lung (RPKM 8.9), bone marrow (RPKM 8.0) and 23 other tissues See more
Orthologs

Genomic context

See HACD4 in Genome Data Viewer
Location:
9p21.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (20999509..21031712, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (21003620..21031635, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene focadhesin Neighboring gene microRNA 491 Neighboring gene small nucleolar RNA, H/ACA box 30B Neighboring gene uncharacterized LOC105375989 Neighboring gene interferon nu 1, pseudogene Neighboring gene interferon beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686F01145, DKFZp686G24132

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3-hydroxy-arachidoyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxy-behenoyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxy-lignoceroyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
3-hydroxyacyl-CoA dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3-hydroxyacyl-CoA dehydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
very-long-chain 3-hydroxyacyl-CoA dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
fatty acid elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid elongation IDA
Inferred from Direct Assay
more info
PubMed 
sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
very long-chain fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4
Names
protein tyrosine phosphatase-like A domain containing 2
protein tyrosine phosphatase-like protein PTPLAD2
protein-tyrosine phosphatase-like A domain-containing protein 2
very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 4
NP_001010915.2
NP_001308812.1
NP_001308832.1
XP_011516178.1
XP_016870202.1
XP_016870203.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010915.5NP_001010915.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform 1

    See identical proteins and their annotated locations for NP_001010915.2

    Status: VALIDATED

    Source sequence(s)
    AL662879, BC114215, BX648779, HY118500
    Consensus CDS
    CCDS43791.1
    UniProtKB/Swiss-Prot
    Q5VWC8
    Related
    ENSP00000419503.1, ENST00000495827.3
    Conserved Domains (1) summary
    pfam04387
    Location:65223
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
  2. NM_001321883.2NP_001308812.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL390882, AL662879, BC114215, BX538052, DA333010
    UniProtKB/Swiss-Prot
    Q5VWC8
    Conserved Domains (1) summary
    pfam04387
    Location:28185
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
  3. NM_001321903.2NP_001308832.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL390882, AL662879
    Conserved Domains (1) summary
    pfam04387
    Location:65273
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    20999509..21031712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014713.1XP_016870202.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X1

  2. XM_017014714.1XP_016870203.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X2

  3. XM_011517876.2XP_011516178.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform X3

    Conserved Domains (1) summary
    cl02156
    Location:1148
    PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

RNA

  1. XR_001746293.1 RNA Sequence

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