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OR2A7 olfactory receptor family 2 subfamily A member 7 [ Homo sapiens (human) ]

Gene ID: 401427, updated on 22-Sep-2022

Summary

Official Symbol
OR2A7provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily A member 7provided by HGNC
Primary source
HGNC:HGNC:8234
See related
Ensembl:ENSG00000243896 AllianceGenome:HGNC:8234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2A21; HSDJ0798C17
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR2A7 in Genome Data Viewer
Location:
7q35
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (144257663..144264792, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143954756..143961885, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ARHGEF35 antisense RNA 1 Neighboring gene olfactory receptor family 2 subfamily A member 42 Neighboring gene OR2A1 antisense RNA 1 Neighboring gene olfactory receptor family 2 subfamily A member 20 pseudogene Neighboring gene Rho guanine nucleotide exchange factor 34, pseudogene Neighboring gene CTAGE family member 8 Neighboring gene olfactory receptor family 2 subfamily A member 9 pseudogene

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 2A7
Names
olfactory receptor OR7-18
olfactory receptor OR7-20
olfactory receptor, family 2, subfamily A, member 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005328.2NP_001005328.1  olfactory receptor 2A7

    See identical proteins and their annotated locations for NP_001005328.1

    Status: VALIDATED

    Source sequence(s)
    AC004889
    Consensus CDS
    CCDS55177.1
    UniProtKB/Swiss-Prot
    Q6IFP4, Q96R45
    UniProtKB/TrEMBL
    A0A126GWD8
    Related
    ENSP00000493320.1, ENST00000641841.1
    Conserved Domains (2) summary
    cd14964
    Location:2551
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:24300
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    144257663..144264792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654715.1 Reference GRCh38.p14 PATCHES

    Range
    212257..219386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)