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PRRT4 proline rich transmembrane protein 4 [ Homo sapiens (human) ]

Gene ID: 401399, updated on 26-Oct-2022

Summary

Official Symbol
PRRT4provided by HGNC
Official Full Name
proline rich transmembrane protein 4provided by HGNC
Primary source
HGNC:HGNC:37280
See related
Ensembl:ENSG00000224940 AllianceGenome:HGNC:37280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 11.2) and fat (RPKM 5.1) See more
Orthologs
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Genomic context

See PRRT4 in Genome Data Viewer
Location:
7q32.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (128350325..128361983, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (129662082..129673442, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (127990379..128001744, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene aurora kinase A pseudogene Neighboring gene RNA binding motif protein 28 Neighboring gene RNA, U7 small nuclear 27 pseudogene Neighboring gene uncharacterized LOC107986845 Neighboring gene inosine monophosphate dehydrogenase 1 Neighboring gene ribosomal protein L37 pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proline-rich transmembrane protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114726.3NP_001108198.2  proline-rich transmembrane protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001108198.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks both an exon in the 5' UTR and a segment in the 3' coding region, which causes a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC010655, BC063892, BU688038
    Consensus CDS
    CCDS47698.2
    UniProtKB/Swiss-Prot
    C9JH25
    Related
    ENSP00000419296.2, ENST00000489835.6
    Conserved Domains (1) summary
    pfam15782
    Location:113304
    GREB1; Gene regulated by oestrogen in breast cancer
  2. NM_001174164.2NP_001167635.1  proline-rich transmembrane protein 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001167635.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC010655, BU688038, BX327107, BX355277
    Consensus CDS
    CCDS55160.1
    UniProtKB/Swiss-Prot
    C9JH25, C9JVW7
    Related
    ENSP00000415026.2, ENST00000446477.6
    Conserved Domains (1) summary
    pfam15782
    Location:113304
    GREB1; Gene regulated by oestrogen in breast cancer
  3. NM_001395429.1NP_001382358.1  proline-rich transmembrane protein 4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC010655
    Consensus CDS
    CCDS55160.1
    UniProtKB/Swiss-Prot
    C9JVW7
    Related
    ENSP00000445239.1, ENST00000535159.5
  4. NM_001405492.1NP_001392421.1  proline-rich transmembrane protein 4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC010655
  5. NM_001405493.1NP_001392422.1  proline-rich transmembrane protein 4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC010655
  6. NM_001405494.1NP_001392423.1  proline-rich transmembrane protein 4 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC010655
    Consensus CDS
    CCDS47698.2
  7. NM_001405495.1NP_001392424.1  proline-rich transmembrane protein 4 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC010655
  8. NM_001405496.1NP_001392425.1  proline-rich transmembrane protein 4 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC010655

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    128350325..128361983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420374.1XP_047276330.1  proline-rich transmembrane protein 4 isoform X4

  2. XM_047420371.1XP_047276327.1  proline-rich transmembrane protein 4 isoform X2

  3. XM_047420368.1XP_047276324.1  proline-rich transmembrane protein 4 isoform X2

  4. XM_047420367.1XP_047276323.1  proline-rich transmembrane protein 4 isoform X1

  5. XM_047420370.1XP_047276326.1  proline-rich transmembrane protein 4 isoform X2

  6. XM_047420366.1XP_047276322.1  proline-rich transmembrane protein 4 isoform X1

  7. XM_047420369.1XP_047276325.1  proline-rich transmembrane protein 4 isoform X2

  8. XM_017012206.2XP_016867695.1  proline-rich transmembrane protein 4 isoform X2

    UniProtKB/Swiss-Prot
    C9JH25
    Conserved Domains (1) summary
    pfam15782
    Location:113304
    GREB1; Gene regulated by oestrogen in breast cancer
  9. XM_047420373.1XP_047276329.1  proline-rich transmembrane protein 4 isoform X4

  10. XM_047420372.1XP_047276328.1  proline-rich transmembrane protein 4 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    129662082..129673442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)