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RAB44 RAB44, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 401258, updated on 5-Aug-2022

Summary

Official Symbol
RAB44provided by HGNC
Official Full Name
RAB44, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:21068
See related
Ensembl:ENSG00000255587 AllianceGenome:HGNC:21068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RASD3; RASL13; dJ431A14.3
Summary
Predicted to enable GTP binding activity; GTPase activity; and calcium ion binding activity. Predicted to be located in azurophil granule membrane; plasma membrane; and specific granule membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 15.4) and lung (RPKM 0.4) See more
Orthologs
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Genomic context

See RAB44 in Genome Data Viewer
Location:
6p21.2
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36697826..36733184)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36518456..36553808)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36665603..36700961)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene promoter of CDKN1A antisense DNA damage activated RNA Neighboring gene leucine aminopeptidase 3 pseudogene 2 Neighboring gene cyclin dependent kinase inhibitor 1A Neighboring gene damage induced long noncoding RNA Neighboring gene G protein-coupled receptor 166 pseudogene Neighboring gene copine 5 Neighboring gene Sharpr-MPRA regulatory region 12831

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43093

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in histamine secretion by mast cell IEA
Inferred from Electronic Annotation
more info
 
involved_in histamine secretion mediated by IgE immunoglobulin IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein Rab-44
Names
RAS-like, family 13
RASD family, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001257357.2NP_001244286.1  ras-related protein Rab-44

    Status: VALIDATED

    Source sequence(s)
    Z85996
    Consensus CDS
    CCDS75442.1
    UniProtKB/Swiss-Prot
    A0A087WXI0
    UniProtKB/TrEMBL
    A0A087WXI0
    Related
    ENSP00000481054.1, ENST00000612677.6
    Conserved Domains (5) summary
    cd00154
    Location:834992
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    pfam13833
    Location:59102
    EF-hand_8; EF-hand domain pair
    cl25732
    Location:191337
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:523831
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:326647
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    36697826..36733184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446435.2XP_024302203.1  ras-related protein Rab-44 isoform X1

    UniProtKB/Swiss-Prot
    A0A087WXI0
    Conserved Domains (5) summary
    cd00154
    Location:834992
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    pfam13833
    Location:59102
    EF-hand_8; EF-hand domain pair
    cl25732
    Location:191337
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:523831
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:326647
    Atrophin-1; Atrophin-1 family
  2. XM_024446439.2XP_024302207.1  ras-related protein Rab-44 isoform X4

    Conserved Domains (5) summary
    pfam13833
    Location:59102
    EF-hand_8; EF-hand domain pair
    cl21455
    Location:834894
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl25732
    Location:191337
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:523831
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:326647
    Atrophin-1; Atrophin-1 family
  3. XM_024446437.2XP_024302205.1  ras-related protein Rab-44 isoform X2

    Conserved Domains (5) summary
    cd00154
    Location:823981
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    pfam13833
    Location:59102
    EF-hand_8; EF-hand domain pair
    cl25732
    Location:191328
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:512820
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:315636
    Atrophin-1; Atrophin-1 family
  4. XM_047418772.1XP_047274728.1  ras-related protein Rab-44 isoform X5

  5. XM_024446441.2XP_024302209.1  ras-related protein Rab-44 isoform X6

    Conserved Domains (5) summary
    pfam13833
    Location:59102
    EF-hand_8; EF-hand domain pair
    cl21455
    Location:831867
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl25732
    Location:191337
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:523831
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:326647
    Atrophin-1; Atrophin-1 family
  6. XM_024446438.2XP_024302206.1  ras-related protein Rab-44 isoform X3

    Conserved Domains (5) summary
    pfam13833
    Location:59102
    EF-hand_8; EF-hand domain pair
    cl21455
    Location:834883
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl25732
    Location:191337
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:523831
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:326647
    Atrophin-1; Atrophin-1 family
  7. XM_024446436.2XP_024302204.1  ras-related protein Rab-44 isoform X1

    UniProtKB/Swiss-Prot
    A0A087WXI0
    Conserved Domains (5) summary
    cd00154
    Location:834992
    Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
    pfam13833
    Location:59102
    EF-hand_8; EF-hand domain pair
    cl25732
    Location:191337
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26386
    Location:523831
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    cl26464
    Location:326647
    Atrophin-1; Atrophin-1 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    36518456..36553808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207498.1: Suppressed sequence

    Description
    NM_207498.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.