Format

Send to:

Choose Destination

RGS7BP regulator of G protein signaling 7 binding protein [ Homo sapiens (human) ]

Gene ID: 401190, updated on 12-Oct-2019

Summary

Official Symbol
RGS7BPprovided by HGNC
Official Full Name
regulator of G protein signaling 7 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:23271
See related
Ensembl:ENSG00000186479 MIM:610890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R7BP
Summary
This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Expression
Biased expression in brain (RPKM 14.8), prostate (RPKM 2.8) and 9 other tissues See more
Orthologs

Genomic context

See RGS7BP in Genome Data Viewer
Location:
5q12.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (64505947..64612330)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (63801774..63909285)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 1A Neighboring gene ring finger protein 180 Neighboring gene RNA, 7SL, cytoplasmic 169, pseudogene Neighboring gene RNA, U6 small nuclear 294, pseudogene Neighboring gene mitochondrial ribosomal protein L49 pseudogene 1 Neighboring gene shisa like 2B Neighboring gene SREK1 interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
anchored component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 7-binding protein
Names
R7 family-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029875.3NP_001025046.1  regulator of G-protein signaling 7-binding protein isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC008854, AK296443, BX640900, DA404068
    Consensus CDS
    CCDS34170.1
    UniProtKB/Swiss-Prot
    Q6MZT1
    Related
    ENSP00000334851.2, ENST00000334025.3
  2. NM_001271890.1NP_001258819.1  regulator of G-protein signaling 7-binding protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks two alternate exons in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC008854, AK296494, BX640900, DA211241
    UniProtKB/Swiss-Prot
    Q6MZT1
    UniProtKB/TrEMBL
    B4DKB7
  3. NM_001271891.1NP_001258820.1  regulator of G-protein signaling 7-binding protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 3) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008854, AC035143, BX640900, DA211241, DC342795
    UniProtKB/Swiss-Prot
    Q6MZT1

RNA

  1. NR_073511.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC008854, AC035143, BX640900, DA211241, DA417118

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    64505947..64612330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248502.4XP_005248559.1  regulator of G-protein signaling 7-binding protein isoform X1

RNA

  1. XR_948251.3 RNA Sequence

Support Center