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RGPD1 RANBP2 like and GRIP domain containing 1 [ Homo sapiens (human) ]

Gene ID: 400966, updated on 24-Nov-2020

Summary

Official Symbol
RGPD1provided by HGNC
Official Full Name
RANBP2 like and GRIP domain containing 1provided by HGNC
Primary source
HGNC:HGNC:32414
See related
Ensembl:ENSG00000187627 MIM:612704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGP1; RGPD2; RanBP2L2; ranBP2L6
Expression
Broad expression in testis (RPKM 17.9), liver (RPKM 7.1) and 23 other tissues See more

Genomic context

See RGPD1 in Genome Data Viewer
Location:
2p11.2
Exon count:
30
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (86913577..87013976)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (87140890..87241099)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374846 Neighboring gene CD8a molecule Neighboring gene CD8b molecule Neighboring gene anaphase promoting complex subunit 1 pseudogene 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 5 Neighboring gene WBP1 pseudogene 1 Neighboring gene plasminogen like B1 Neighboring gene ANAPC1 pseudogene 2 Neighboring gene uncharacterized LOC107985772 Neighboring gene tRNA-Pro (anticodon AGG) 4-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ58076

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RANBP2-like and GRIP domain-containing protein 1
Names
RANBP2-like and GRIP domain-containing protein 1/2
ran-binding protein 2-like 2/6
ran-binding protein 2-like 6
ranBP2-like 2/6
ranBP2-like 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024457.4NP_001019628.3  RANBP2-like and GRIP domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001019628.3

    Status: VALIDATED

    Source sequence(s)
    AC111200, CR749330
    Consensus CDS
    CCDS46358.2
    UniProtKB/Swiss-Prot
    P0DJD0
    Related
    ENSP00000386808.2, ENST00000409776.6
    Conserved Domains (8) summary
    smart00028
    Location:5182
    TPR; Tetratricopeptide repeats
    COG5171
    Location:9601152
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10361152
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13331449
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:5080
    TPR; TPR repeat [structural motif]
    pfam01465
    Location:16901732
    GRIP; GRIP domain
    pfam13414
    Location:50117
    TPR_11; TPR repeat
    pfam16704
    Location:16261686
    Rab_bind; Rab binding domain
  2. NM_001382344.1NP_001369273.1  RANBP2-like and GRIP domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC111200
    Related
    ENSP00000492954.1, ENST00000641458.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    86913577..87013976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004106.2XP_016859595.1  RANBP2-like and GRIP domain-containing protein 1 isoform X5

  2. XM_011532849.3XP_011531151.1  RANBP2-like and GRIP domain-containing protein 1 isoform X6

    Conserved Domains (6) summary
    smart00028
    Location:104135
    TPR; Tetratricopeptide repeats
    COG5171
    Location:10131205
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10891205
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13861502
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:103133
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:103170
    TPR_11; TPR repeat
  3. XM_017004103.2XP_016859592.1  RANBP2-like and GRIP domain-containing protein 1 isoform X1

  4. XM_011532850.2XP_011531152.1  RANBP2-like and GRIP domain-containing protein 1 isoform X7

    Conserved Domains (6) summary
    smart00028
    Location:104135
    TPR; Tetratricopeptide repeats
    COG5171
    Location:10131205
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10891205
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13861502
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:103133
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:103170
    TPR_11; TPR repeat
  5. XM_011532852.3XP_011531154.1  RANBP2-like and GRIP domain-containing protein 1 isoform X9

    Conserved Domains (6) summary
    smart00028
    Location:104135
    TPR; Tetratricopeptide repeats
    COG5171
    Location:10131205
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10891205
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13861502
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:103133
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:103170
    TPR_11; TPR repeat
  6. XM_011532851.3XP_011531153.1  RANBP2-like and GRIP domain-containing protein 1 isoform X8

    Conserved Domains (6) summary
    smart00028
    Location:104135
    TPR; Tetratricopeptide repeats
    COG5171
    Location:10131205
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10891205
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13861502
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:103133
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:103170
    TPR_11; TPR repeat
  7. XM_011532845.3XP_011531147.1  RANBP2-like and GRIP domain-containing protein 1 isoform X2

    Conserved Domains (8) summary
    smart00028
    Location:104135
    TPR; Tetratricopeptide repeats
    COG5171
    Location:10131205
    YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
    cd13177
    Location:10891205
    RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
    cd14685
    Location:13861502
    RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
    sd00006
    Location:103133
    TPR; TPR repeat [structural motif]
    pfam01465
    Location:17431785
    GRIP; GRIP domain
    pfam13414
    Location:103170
    TPR_11; TPR repeat
    pfam16704
    Location:16791739
    Rab_bind; Rab binding domain
  8. XM_017004104.1XP_016859593.1  RANBP2-like and GRIP domain-containing protein 1 isoform X3

  9. XM_017004105.2XP_016859594.1  RANBP2-like and GRIP domain-containing protein 1 isoform X4

RNA

  1. XR_002959299.1 RNA Sequence

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