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PAIP2B poly(A) binding protein interacting protein 2B [ Homo sapiens (human) ]

Gene ID: 400961, updated on 11-Jun-2021

Summary

Official Symbol
PAIP2Bprovided by HGNC
Official Full Name
poly(A) binding protein interacting protein 2Bprovided by HGNC
Primary source
HGNC:HGNC:29200
See related
Ensembl:ENSG00000124374 MIM:611018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in brain (RPKM 9.7), thyroid (RPKM 9.0) and 23 other tissues See more
Orthologs
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Genomic context

See PAIP2B in Genome Data Viewer
Location:
2p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (71182738..71227110, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (71409868..71454233, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene M-phase phosphoprotein 10 Neighboring gene methylmalonyl-CoA epimerase Neighboring gene uncharacterized LOC105374797 Neighboring gene Sharpr-MPRA regulatory region 7735 Neighboring gene zinc finger protein 638

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation repressor activity, mRNA regulatory element binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
polyadenylate-binding protein-interacting protein 2B
Names
PABP-interacting protein 2B
PAIP-2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020459.1NP_065192.1  polyadenylate-binding protein-interacting protein 2B

    See identical proteins and their annotated locations for NP_065192.1

    Status: VALIDATED

    Source sequence(s)
    AB032981, AC007881, DA247526, DA346299
    Consensus CDS
    CCDS46322.1
    UniProtKB/Swiss-Prot
    Q9ULR5
    Related
    ENSP00000244221.8, ENST00000244221.9
    Conserved Domains (1) summary
    pfam07145
    Location:107120
    PAM2; Ataxin-2 C-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    71182738..71227110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532843.2XP_011531145.1  polyadenylate-binding protein-interacting protein 2B isoform X2

    See identical proteins and their annotated locations for XP_011531145.1

    UniProtKB/Swiss-Prot
    Q9ULR5
    Conserved Domains (1) summary
    pfam07145
    Location:107120
    PAM2; Ataxin-2 C-terminal region
  2. XM_005264311.4XP_005264368.1  polyadenylate-binding protein-interacting protein 2B isoform X2

    See identical proteins and their annotated locations for XP_005264368.1

    UniProtKB/Swiss-Prot
    Q9ULR5
    Conserved Domains (1) summary
    pfam07145
    Location:107120
    PAM2; Ataxin-2 C-terminal region
  3. XM_011532842.3XP_011531144.1  polyadenylate-binding protein-interacting protein 2B isoform X1

    See identical proteins and their annotated locations for XP_011531144.1

    Conserved Domains (1) summary
    pfam07145
    Location:127141
    PAM2; Ataxin-2 C-terminal region
  4. XM_005264310.4XP_005264367.1  polyadenylate-binding protein-interacting protein 2B isoform X2

    See identical proteins and their annotated locations for XP_005264367.1

    UniProtKB/Swiss-Prot
    Q9ULR5
    Conserved Domains (1) summary
    pfam07145
    Location:107120
    PAM2; Ataxin-2 C-terminal region
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