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fz2 frizzled 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40090, updated on 6-Jul-2021

Summary

Official Symbol
fz2provided by FlyBase
Official Full Name
frizzled 2provided by FlyBase
Primary source
FLYBASE:FBgn0016797
Locus tag
Dmel_CG9739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9739; D-fz2; D-Fz2; Dfrz2; dfz(2); DFz-2; dfz2; dFz2; Dfz2; DFz2; DFZ2; DFz2C; dfz2r; Dfz[[2]]; Dm Fz2; Dmel\CG9739; frz2; fz-2; Fz2; FZ2
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Genomic context

See fz2 in Genome Data Viewer
Location:
75F9-76A3; 3-45 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19140975..19235373, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19134075..19228473, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Gemin 2 Neighboring gene uncharacterized protein Neighboring gene Serpin 75F Neighboring gene long non-coding RNA:CR45941 Neighboring gene long non-coding RNA:CR43893 Neighboring gene long non-coding RNA:CR43892 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

mobile_element

  • Loc: c19209429-19208114 mobile_element_type = transposon:Doc{}1048

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Wnt-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables Wnt-activated receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Wnt-protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardioblast cell fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chitin-based larval cuticle pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in female gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing margin morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in imaginal disc-derived wing margin morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in midgut development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron fate specification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in segment polarity determination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synapse organization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in synaptic target inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with early endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
frizzled 2
Names
CG9739-PA
CG9739-PB
CG9739-PC
CG9739-PD
CG9739-PE
CG9739-PF
CG9739-PG
D-frizzled2
DFrizzled2
Dfrizzled[[2]]
drosophila frizzled 2
drosophila frizzled2
frizzled-2
frizzled2
fz2-PA
fz2-PB
fz2-PC
fz2-PD
fz2-PE
fz2-PF
fz2-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19140975..19235373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275109.1NP_001262038.1  frizzled 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262038.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVX3
    UniProtKB/TrEMBL
    B7Z072
    Related
    FBpp0304981, FBtr0332735
    Conserved Domains (2) summary
    cd07456
    Location:63182
    CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5
    pfam01534
    Location:308618
    Frizzled; Frizzled/Smoothened family membrane region
  2. NM_001104173.3NP_001097643.1  frizzled 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097643.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVX3
    UniProtKB/TrEMBL
    B7Z072
    Related
    FBpp0111803, FBtr0112890
    Conserved Domains (2) summary
    cd07456
    Location:63182
    CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5
    pfam01534
    Location:308618
    Frizzled; Frizzled/Smoothened family membrane region
  3. NM_001275107.1NP_001262036.1  frizzled 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262036.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVX3
    UniProtKB/TrEMBL
    B7Z072
    Related
    FBpp0303227, FBtr0330194
    Conserved Domains (2) summary
    cd07456
    Location:63182
    CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5
    pfam01534
    Location:308618
    Frizzled; Frizzled/Smoothened family membrane region
  4. NM_001144499.3NP_001137971.1  frizzled 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137971.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVX3
    UniProtKB/TrEMBL
    B7Z072
    Related
    FBpp0288861, FBtr0299586
    Conserved Domains (2) summary
    cd07456
    Location:63182
    CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5
    pfam01534
    Location:308618
    Frizzled; Frizzled/Smoothened family membrane region
  5. NM_168787.3NP_730389.1  frizzled 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730389.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVX3
    UniProtKB/TrEMBL
    B7Z072
    Related
    FBpp0074795, FBtr0075028
    Conserved Domains (2) summary
    cd07456
    Location:63182
    CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5
    pfam01534
    Location:308618
    Frizzled; Frizzled/Smoothened family membrane region
  6. NM_001275108.2NP_001262037.1  frizzled 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262037.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFW3
    Related
    FBpp0303228, FBtr0330195
    Conserved Domains (2) summary
    cd07456
    Location:63182
    CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5
    pfam01534
    Location:308618
    Frizzled; Frizzled/Smoothened family membrane region
  7. NM_079431.2NP_524155.1  frizzled 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524155.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVX3
    UniProtKB/TrEMBL
    B7Z072
    Related
    FBpp0074796, FBtr0075029
    Conserved Domains (2) summary
    cd07456
    Location:63182
    CRD_FZ5_like; Cysteine-rich Wnt-binding domain (CRD) of receptors similar to frizzled 5
    pfam01534
    Location:308618
    Frizzled; Frizzled/Smoothened family membrane region
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