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Naxd NAD(P)HX dehydratase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40085, updated on 11-Sep-2024

Summary

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Official Symbol
Naxdprovided by FlyBase
Official Full Name
NAD(P)HX dehydrataseprovided by FlyBase
Primary source
FLYBASE:FBgn0036848
Locus tag
Dmel_CG10424
See related
AllianceGenome:FB:FBgn0036848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10424; Dmel\CG10424
Summary
Predicted to enable ATP-dependent NAD(P)H-hydrate dehydratase activity. Predicted to be involved in metabolite repair. Is expressed in adult head; embryonic/larval midgut; and organism. Orthologous to human NAXD (NAD(P)HX dehydratase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Naxd in Genome Data Viewer
Location:
75F7-75F7; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19096399..19097709, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19089499..19090809, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Misexpression suppressor of ras 6 Neighboring gene Canopy b Neighboring gene uncharacterized protein Neighboring gene Gemin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combining mapping and arraying: An approach to candidate gene identification. Wayne ML, et al. Proc Natl Acad Sci U S A, 2002 Nov 12. PMID 12415114, Free PMC Article
  2. FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction. Gupta A, et al. Elife, 2020 Jun 11. PMID 32525804, Free PMC Article
  3. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article
  4. Hematopoietic plasticity mapped in Drosophila and other insects. Hultmark D, et al. Elife, 2022 Aug 3. PMID 35920811, Free PMC Article
  5. Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila. Cho B, et al. Nat Commun, 2020 Sep 8. PMID 32900993, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP-dependent NAD(P)H-hydrate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in metabolite repair IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NAD(P)HX dehydratase
Names
CG10424-PA
Naxd-PA
NP_649090.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    19096399..19097709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140833.3 → NP_649090.1  NAD(P)HX dehydratase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649090.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VVW8
    Related
    FBpp0074800
    Conserved Domains (1) summary
    cd01171
    Location:28 → 287
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VVW8.1 Q9VVW8

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