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DEFB132 defensin beta 132 [ Homo sapiens (human) ]

Gene ID: 400830, updated on 10-Dec-2024

Summary

Official Symbol
DEFB132provided by HGNC
Official Full Name
defensin beta 132provided by HGNC
Primary source
HGNC:HGNC:33806
See related
Ensembl:ENSG00000186458 AllianceGenome:HGNC:33806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BD-32; DEFB32; HEL-75; UNQ827; DEFB-32; KFLL827
Summary
Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. This protein binds spermatozoa and has antimicrobial activity against E. coli. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Expression
Restricted expression toward fat (RPKM 25.0) See more
Orthologs
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Genomic context

See DEFB132 in Genome Data Viewer
Location:
20p13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (257724..261096)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (300270..303642)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (238365..241737)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene defensin beta 128 Neighboring gene defensin beta 129 Neighboring gene chromosome 20 open reading frame 96 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12561 Neighboring gene zinc finger CCHC-type containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
beta-defensin 132
Names
RP5-1103G7.6
beta-defensin 32
defensin HEL-75
defensin, beta 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207469.3NP_997352.1  beta-defensin 132 precursor

    See identical proteins and their annotated locations for NP_997352.1

    Status: REVIEWED

    Source sequence(s)
    AL034548, AY358708, BC137292, BE044548
    Consensus CDS
    CCDS12993.1
    UniProtKB/Swiss-Prot
    B2RP72, Q4QY40, Q7Z7B7
    Related
    ENSP00000371813.3, ENST00000382376.4
    Conserved Domains (1) summary
    pfam13841
    Location:2656
    Defensin_beta_2; Beta defensin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    257724..261096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    300270..303642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)