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SH2D5 SH2 domain containing 5 [ Homo sapiens (human) ]

Gene ID: 400745, updated on 11-Jun-2021

Summary

Official Symbol
SH2D5provided by HGNC
Official Full Name
SH2 domain containing 5provided by HGNC
Primary source
HGNC:HGNC:28819
See related
Ensembl:ENSG00000189410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 4.0), testis (RPKM 2.1) and 3 other tissues See more
Orthologs
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Genomic context

See SH2D5 in Genome Data Viewer
Location:
1p36.12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (20719731..20732703, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (21046224..21059196, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PINK1 antisense RNA Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Neighboring gene kinesin family member 17 Neighboring gene heterochromatin protein 1 binding protein 3 Neighboring gene eukaryotic translation initiation factor 4 gamma 3 Neighboring gene RNA, U7 small nuclear 200 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41242, FLJ41847, FLJ42879

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
SH2 domain-containing protein 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103160.2NP_001096630.1  SH2 domain-containing protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001096630.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and the resulting predicted protein isoform (2) has a shorter N-terminus.
    Source sequence(s)
    AK124869, AL663074
    Consensus CDS
    CCDS41280.1
    UniProtKB/Swiss-Prot
    Q6ZV89
    Related
    ENSP00000364171.1, ENST00000375031.5
    Conserved Domains (2) summary
    cd00173
    Location:212288
    SH2; Src homology 2 (SH2) domain
    cl17171
    Location:166
    PH-like; Pleckstrin homology-like domain
  2. NM_001103161.2NP_001096631.1  SH2 domain-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001096631.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) includes an alternate exon and encodes a predicted protein isoform (1) with a longer N-terminus compared to isoform 2.
    Source sequence(s)
    AK124869, AL663074, DC382086
    Consensus CDS
    CCDS44080.1
    UniProtKB/Swiss-Prot
    Q6ZV89
    Related
    ENSP00000406026.2, ENST00000444387.7
    Conserved Domains (2) summary
    cd00173
    Location:296372
    SH2; Src homology 2 (SH2) domain
    cd13157
    Location:23150
    PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    20719731..20732703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541461.2XP_011539763.1  SH2 domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011539763.1

    UniProtKB/Swiss-Prot
    Q6ZV89
    Conserved Domains (2) summary
    cd00173
    Location:296372
    SH2; Src homology 2 (SH2) domain
    cd13157
    Location:23150
    PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain
  2. XM_011541460.2XP_011539762.1  SH2 domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011539762.1

    UniProtKB/Swiss-Prot
    Q6ZV89
    Conserved Domains (2) summary
    cd00173
    Location:296372
    SH2; Src homology 2 (SH2) domain
    cd13157
    Location:23150
    PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain
  3. XM_011541462.2XP_011539764.1  SH2 domain-containing protein 5 isoform X2

    Conserved Domains (2) summary
    cd00173
    Location:295371
    SH2; Src homology 2 (SH2) domain
    cd13157
    Location:23150
    PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain
  4. XM_011541459.2XP_011539761.1  SH2 domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011539761.1

    UniProtKB/Swiss-Prot
    Q6ZV89
    Conserved Domains (2) summary
    cd00173
    Location:296372
    SH2; Src homology 2 (SH2) domain
    cd13157
    Location:23150
    PTB_tensin-related; Tensin-related Phosphotyrosine-binding (PTB) domain
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