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ZNF772 zinc finger protein 772 [ Homo sapiens (human) ]

Gene ID: 400720, updated on 8-Dec-2022

Summary

Official Symbol
ZNF772provided by HGNC
Official Full Name
zinc finger protein 772provided by HGNC
Primary source
HGNC:HGNC:33106
See related
Ensembl:ENSG00000197128 AllianceGenome:HGNC:33106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 1.7), testis (RPKM 0.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF772 in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57469586..57477566, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60566631..60574608, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57980954..57988934, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 1 Neighboring gene vomeronasal 1 receptor 107 pseudogene Neighboring gene zinc finger protein 419 Neighboring gene zinc finger protein 773

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686I1569

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051489.1 RefSeqGene

    Range
    5005..12985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024596.3NP_001019767.1  zinc finger protein 772 isoform 1

    See identical proteins and their annotated locations for NP_001019767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AC003005, AC004076, BC150292, BX647068
    Consensus CDS
    CCDS33133.1
    UniProtKB/Swiss-Prot
    B4DYS0, Q68DY9
    Related
    ENSP00000341165.4, ENST00000343280.8
    Conserved Domains (6) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:158464
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:268288
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:266288
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:280305
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001144068.2NP_001137540.1  zinc finger protein 772 isoform 2

    See identical proteins and their annotated locations for NP_001137540.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC003005, AC004076, AK302574, BC150292, BX647068
    Consensus CDS
    CCDS46210.1
    UniProtKB/Swiss-Prot
    Q68DY9
    Related
    ENSP00000348992.3, ENST00000356584.8
    Conserved Domains (6) summary
    smart00349
    Location:2768
    KRAB; krueppel associated box
    COG5048
    Location:117423
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:225247
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:239264
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001330613.2NP_001317542.1  zinc finger protein 772 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant differs in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC003005, AC004076, AK294941, BC150292, DB450372
    Consensus CDS
    CCDS82406.1
    UniProtKB/Swiss-Prot
    Q68DY9

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57469586..57477566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258944.5XP_005259001.1  zinc finger protein 772 isoform X2

    See identical proteins and their annotated locations for XP_005259001.1

    UniProtKB/Swiss-Prot
    Q68DY9
    Related
    ENSP00000395967.2, ENST00000427512.6
    Conserved Domains (4) summary
    COG5048
    Location:46352
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:156176
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:154176
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:168193
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011526980.4XP_011525282.1  zinc finger protein 772 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:103409
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:213233
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:211233
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:225250
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60566631..60574608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)