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PRSS57 serine protease 57 [ Homo sapiens (human) ]

Gene ID: 400668, updated on 29-Mar-2018

Summary

Official Symbol
PRSS57provided by HGNC
Official Full Name
serine protease 57provided by HGNC
Primary source
HGNC:HGNC:31397
See related
Ensembl:ENSG00000185198 Vega:OTTHUMG00000180662
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSP4; PRSSL1; UNQ782
Summary
This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. [provided by RefSeq, Jul 2016]
Expression
Restricted expression toward bone marrow (RPKM 54.0) See more
Orthologs

Genomic context

See PRSS57 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (685521..695461, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (685546..695462, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 126 Neighboring gene follistatin like 3 Neighboring gene ribosomal protein S2 pseudogene 52 Neighboring gene paralemmin Neighboring gene mitotic spindle positioning

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
azurophil granule lumen IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine protease 57
Names
neutrophil serine protease 4
protease, serine 57
serine protease 1-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051189.1 RefSeqGene

    Range
    5071..15011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001308209.1NP_001295138.1  serine protease 57 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC112708, BC144505, D19687
    Consensus CDS
    CCDS77203.1
    UniProtKB/TrEMBL
    B7ZMF6
    Related
    ENSP00000327386.6, OTTHUMP00000275100, ENST00000329267.8, OTTHUMT00000474759
    Conserved Domains (2) summary
    smart00020
    Location:33257
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:33257
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_214710.4NP_999875.1  serine protease 57 isoform 1 precursor

    See identical proteins and their annotated locations for NP_999875.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC112708, AY358594, D19687
    Consensus CDS
    CCDS12041.1
    UniProtKB/Swiss-Prot
    Q6UWY2
    Related
    ENSP00000482358.1, OTTHUMP00000264931, ENST00000613411.4, OTTHUMT00000452480
    Conserved Domains (1) summary
    cd00190
    Location:34258
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    685521..695461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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