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PRSS57 serine protease 57 [ Homo sapiens (human) ]

Gene ID: 400668, updated on 5-Jul-2025
Official Symbol
PRSS57provided by HGNC
Official Full Name
serine protease 57provided by HGNC
Primary source
HGNC:HGNC:31397
See related
Ensembl:ENSG00000185198 AllianceGenome:HGNC:31397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSP4; PRSSL1; UNQ782
Summary
This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. [provided by RefSeq, Jul 2016]
Expression
Restricted expression toward bone marrow (RPKM 54.0) See more
Orthologs
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See PRSS57 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (685546..695452, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (639634..649468, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (685546..695452, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:657815-658727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:658728-659641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:678746-679248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9616 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:680933-681482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:681483-682031 Neighboring gene follistatin like 3 Neighboring gene ribosomal protein S2 pseudogene 52 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:704097-705067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:707932-708492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:718052-718584 Neighboring gene paralemmin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9621 Neighboring gene mitotic spindle positioning

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in azurophil granule lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in azurophil granule lumen IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine protease 57
Names
neutrophil serine protease 4
protease, serine 57
serine protease 1-like protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051189.2 RefSeqGene

    Range
    5000..14906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001308209.2NP_001295138.2  serine protease 57 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC004156, AC112708
    Consensus CDS
    CCDS77203.1
    UniProtKB/TrEMBL
    A0A0A0MR61, B7ZMF6
    Related
    ENSP00000327386.6, ENST00000329267.9
    Conserved Domains (1) summary
    cd00190
    Location:33257
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_214710.5NP_999875.2  serine protease 57 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004156, AC112708
    Consensus CDS
    CCDS12041.1
    UniProtKB/Swiss-Prot
    B2RNW8, Q6UWY2
    UniProtKB/TrEMBL
    B7ZMF6
    Related
    ENSP00000482358.1, ENST00000613411.4
    Conserved Domains (1) summary
    cd00190
    Location:34258
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    685546..695452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    639634..649468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)