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GRAPL GRB2 related adaptor protein like [ Homo sapiens (human) ]

Gene ID: 400581, updated on 25-Jan-2022

Summary

Official Symbol
GRAPLprovided by HGNC
Official Full Name
GRB2 related adaptor protein likeprovided by HGNC
Primary source
HGNC:HGNC:37240
See related
Ensembl:ENSG00000189152 AllianceGenome:HGNC:37240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in cell migration and signal transduction. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in spleen (RPKM 4.2), lymph node (RPKM 2.8) and 13 other tissues See more
Orthologs
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Genomic context

See GRAPL in Genome Data Viewer
Location:
17p11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (19123189..19159187)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19030902..19062500)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized protein ENSP00000382042-like Neighboring gene small nucleolar RNA, C/D box 3D Neighboring gene GRAPL antisense RNA 1 Neighboring gene kynureninase pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 3A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GRB2-related adapter protein-like
Names
GRB2-related adapter protein LOC400581

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001129778.3NP_001123250.1  GRB2-related adapter protein-like isoform 1

    See identical proteins and their annotated locations for NP_001123250.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007952
    Consensus CDS
    CCDS45627.1
    UniProtKB/Swiss-Prot
    Q8TC17
    Related
    ENSP00000437409.2, ENST00000344415.9
    Conserved Domains (2) summary
    cd11948
    Location:255
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cl15255
    Location:56101
    SH2; Src homology 2 (SH2) domain
  2. NM_001353418.2NP_001340347.1  GRB2-related adapter protein-like isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 3' coding sequence compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC007952
    Related
    ENSP00000466091.1, ENST00000577213.1
    Conserved Domains (2) summary
    cd11948
    Location:255
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cl15255
    Location:56100
    SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    19123189..19159187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024635.2XP_016880124.1  GRB2-related adapter protein-like isoform X1

  2. XM_017024637.1XP_016880126.1  GRB2-related adapter protein-like isoform X2

    UniProtKB/Swiss-Prot
    Q8TC17
    Conserved Domains (2) summary
    cd11948
    Location:255
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cl15255
    Location:56101
    SH2; Src homology 2 (SH2) domain
  3. XM_011523857.3XP_011522159.1  GRB2-related adapter protein-like isoform X3

    UniProtKB/TrEMBL
    J3QRP9
    Conserved Domains (2) summary
    cd11948
    Location:255
    SH3_GRAP_N; N-terminal Src homology 3 domain of GRB2-related adaptor protein
    cl15255
    Location:56100
    SH2; Src homology 2 (SH2) domain
  4. XM_017024636.2XP_016880125.1  GRB2-related adapter protein-like isoform X1

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