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CG3961 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40056, updated on 5-Jul-2025
Official Symbol
CG3961provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036821
Locus tag
Dmel_CG3961
See related
AllianceGenome:FB:FBgn0036821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACSL1; ACSL1/5/6; ACSL5; ACSL5/6; Dmel\CG3961
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to be located in mitochondrion. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; larval imaginal tissue; and sense organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congenital diarrhea; and leukemia. Orthologous to several human genes including ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CG3961 in Genome Data Viewer
Location:
75E3-75E4; 3-45 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18878250..18890483, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18871350..18883583, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 3 Neighboring gene Rad9 Neighboring gene UDP-glucose-glycoprotein glucosyltransferase Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Ninjurin B

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. High-Fat Diet Induces Oxidative Stress and MPK2 and HSP83 Gene Expression in Drosophila melanogaster. Trindade de Paula M, et al. Oxid Med Cell Longev, 2016. PMID 27579152, Free PMC Article
  2. A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster. Nunes RD, et al. Development, 2023 Oct 15. PMID 37795747, Free PMC Article
  3. Expression level of sarah, a homolog of DSCR1, is critical for ovulation and female courtship behavior in Drosophila melanogaster. Ejima A, et al. Genetics, 2004 Dec. PMID 15611177, Free PMC Article
  4. Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase. Oba Y, et al. Biosci Biotechnol Biochem, 2005 Apr. PMID 15849423
  5. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Wilfling F, et al. Dev Cell, 2013 Feb 25. PMID 23415954, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
uncharacterized protein
Names
CG3961-PA
CG3961-PC
CG3961-PD
CG3961-PE
NP_001262024.1
NP_649067.2
NP_730369.1
NP_730370.2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18878250..18890483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140810.4 → NP_649067.2  uncharacterized protein Dmel_CG3961, isoform C

    See identical proteins and their annotated locations for NP_649067.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95R88, Q9VVT8
    Related
    FBpp0074845
    Conserved Domains (1) summary
    cd05927
    Location:130 → 701
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. NM_168781.3 → NP_730369.1  uncharacterized protein Dmel_CG3961, isoform A

    See identical proteins and their annotated locations for NP_730369.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95R88, Q9VVT8
    Related
    FBpp0074844
    Conserved Domains (1) summary
    cd05927
    Location:130 → 701
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. NM_001275095.1 → NP_001262024.1  uncharacterized protein Dmel_CG3961, isoform E

    See identical proteins and their annotated locations for NP_001262024.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCX4, Q95R88
    Conserved Domains (1) summary
    cd05927
    Location:92 → 663
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  4. NM_168782.2 → NP_730370.2  uncharacterized protein Dmel_CG3961, isoform D

    See identical proteins and their annotated locations for NP_730370.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2QCY2, Q95R88
    Conserved Domains (1) summary
    cd05927
    Location:80 → 651
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QCY2 E2QCY2
M9PCX4 M9PCX4
Q95R88 Q95R88
Q960G4 Q960G4
Q9VVT8 Q9VVT8

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