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FENDRR FOXF1 adjacent non-coding developmental regulatory RNA [ Homo sapiens (human) ]

Gene ID: 400550, updated on 5-Jan-2022

Summary

Official Symbol
FENDRRprovided by HGNC
Official Full Name
FOXF1 adjacent non-coding developmental regulatory RNAprovided by HGNC
Primary source
HGNC:HGNC:43894
See related
Ensembl:ENSG00000268388 MIM:614975
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOXF1AS1; FOXF1-AS1; lincFOXF1; TCONS_00024240; onco-lncRNA-21
Summary
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Expression
Biased expression in lung (RPKM 13.0), urinary bladder (RPKM 9.3) and 9 other tissues See more
Orthologs
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Genomic context

See FENDRR in Genome Data Viewer
Location:
16q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (86474525..86508860, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (86508131..86542466, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1422 Neighboring gene chloride intracellular channel 1 pseudogene Neighboring gene forkhead box F1 Neighboring gene ribosomal protein L7a pseudogene 63

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
EBI GWAS Catalog

General gene information

Markers

Homology

Other Names

  • FOXF1 antisense RNA 1 (head to head)
  • FOXF1 antisense RNA 1 (non-protein coding)

Clone Names

  • FLJ34515, FLJ39993, DKFZp666B056, DKFZp686B02156

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_033925.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC009108, AC125792, AK091834, BQ671983
    Related
    ENST00000595886.1
  2. NR_036444.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) shares the first exon with variant 1, but has an alternate combination of 3' exons.
    Source sequence(s)
    AC009108, AK091834, CB049925
    Related
    ENST00000599749.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    86474525..86508860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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