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FENDRR FOXF1 adjacent non-coding developmental regulatory RNA [ Homo sapiens (human) ]

Gene ID: 400550, updated on 3-Mar-2026
Official Symbol
FENDRRprovided by HGNC
Official Full Name
FOXF1 adjacent non-coding developmental regulatory RNAprovided by HGNC
Primary source
HGNC:HGNC:43894
See related
Ensembl:ENSG00000268388 MIM:614975; AllianceGenome:HGNC:43894
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOXF1AS1; FOXF1-AS1; lincFOXF1; TCONS_00024240; onco-lncRNA-21
Summary
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Expression
Biased expression in lung (RPKM 13.0), urinary bladder (RPKM 9.3) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See FENDRR in Genome Data Viewer
Location:
16q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (86474525..86508860, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (92542762..92577081, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (86508131..86542466, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8769 Neighboring gene long intergenic non-protein coding RNA 917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:86393693-86394193 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:86410784-86411320 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46362 Neighboring gene LINC00917-FENDRR intergenic CAGE-defined mid-level expression enhancer Neighboring gene VISTA enhancer hs1 Neighboring gene Sharpr-MPRA regulatory region 1422 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:86466900-86467129 Neighboring gene CLIC1 pseudogene 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:86499943-86501142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:86531905-86532529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:86534107-86534663 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:86545626-86546392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:86555369-86555869 Neighboring gene forkhead box F1 Neighboring gene ribosomal protein L7a pseudogene 63

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The Emerging Role of LncRNA FENDRR in Multiple Cancers: A Review. Fazaeli H, et al. Curr Mol Med, 2023 May 30. PMID 35579154
  2. LncRNA FENDRR represses proliferation, migration and invasion through suppression of survivin in cholangiocarcinoma cells. Qin X, et al. Cell Cycle, 2019 Apr. PMID 30983519, Free PMC Article
  3. LncRNA Fendrr inhibits hypoxia/reoxygenation-induced cardiomyocyte apoptosis by downregulating p53 expression. Li X, et al. J Pharm Pharmacol, 2020 Sep. PMID 32537758
  4. Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNA FENDRR in Lung Cancer in Xuanwei, China. Duan Y, et al. Nutr Cancer, 2021. PMID 32590916
  5. Decreased long non-coding RNA lincFOXF1 indicates poor progression and promotes cell migration and metastasis in osteosarcoma. Yang S, et al. J Cell Mol Med, 2020 Nov. PMID 32945076, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA FENDRR regulates proliferation, apoptosis and migration in high-glucose-induced human retinal endothelial cells via targeting miR-384/RHOA axis.
    Title: Long non-coding RNA FENDRR regulates proliferation, apoptosis and migration in high-glucose-induced human retinal endothelial cells via targeting miR-384/RHOA axis.
  2. The Emerging Role of LncRNA FENDRR in Multiple Cancers: A Review.
    Title: The Emerging Role of LncRNA FENDRR in Multiple Cancers: A Review.
  3. An integrated analysis of the competing endogenous RNA network associated of prognosis of stage I lung adenocarcinoma.
    Title: An integrated analysis of the competing endogenous RNA network associated of prognosis of stage I lung adenocarcinoma.
  4. Long non-coding RNA FENDRR inhibits the stemenss of colorectal cancer cells through directly binding to Sox2 RNA.
    Title: Long non-coding RNA FENDRR inhibits the stemenss of colorectal cancer cells through directly binding to Sox2 RNA.
  5. Lung-specific distant enhancer cis regulates expression of FOXF1 and lncRNA FENDRR.
    Title: Lung-specific distant enhancer cis regulates expression of FOXF1 and lncRNA FENDRR.
  6. FENDRR Sponges miR-424-5p to Inhibit Cell Proliferation, Migration and Invasion in Colorectal Cancer.
    Title: FENDRR Sponges miR-424-5p to Inhibit Cell Proliferation, Migration and Invasion in Colorectal Cancer.
  7. LncRNA FENDRR Expression Correlates with Tumor Immunogenicity.
    Title: LncRNA FENDRR Expression Correlates with Tumor Immunogenicity.
  8. Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNA FENDRR in Lung Cancer in Xuanwei, China.
    Title: Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNA FENDRR in Lung Cancer in Xuanwei, China.
  9. Long Noncoding RNA FENDRR Inhibits Lung Fibroblast Proliferation via a Reduction of beta-Catenin.
    Title: Long Noncoding RNA FENDRR Inhibits Lung Fibroblast Proliferation via a Reduction of β-Catenin.
  10. N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma.
    Title: N-methyladenosine reader YTHDF2-mediated long noncoding RNA FENDRR degradation promotes cell proliferation in endometrioid endometrial carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Other Names

  • FOXF1 antisense RNA 1 (head to head)
  • FOXF1 antisense RNA 1 (non-protein coding)

Clone Names

  • FLJ34515, FLJ39993, DKFZp666B056, DKFZp686B02156

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_033925.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC009108, AC125792, AK091834, BQ671983
    Related
    ENST00000595886.1

  2. NR_036444.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) shares the first exon with variant 1, but has an alternate combination of 3' exons.
    Source sequence(s)
    AC009108, AK091834, CB049925
    Related
    ENST00000599749.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    86474525..86508860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    92542762..92577081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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