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KNOP1 lysine rich nucleolar protein 1 [ Homo sapiens (human) ]

Gene ID: 400506, updated on 1-Aug-2020

Summary

Official Symbol
KNOP1provided by HGNC
Official Full Name
lysine rich nucleolar protein 1provided by HGNC
Primary source
HGNC:HGNC:34404
See related
Ensembl:ENSG00000103550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSG118; FAM191A; 101F10.1; C16orf88
Summary
The protein encoded by this gene is a nucleolar protein that interacts with zinc finger 106 protein. The encoded protein has several of the same characteristics as nucleostemin and may be involved in testis development. [provided by RefSeq, Feb 2017]
Expression
Ubiquitous expression in testis (RPKM 5.4), placenta (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See KNOP1 in Genome Data Viewer
Location:
16p12.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (19701937..19718227, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (19717673..19729726, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene centriolar coiled-coil protein 110 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene IQ motif containing K Neighboring gene uncharacterized LOC105371115 Neighboring gene LARP7 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of lysine-rich nucleolar protein 1 (C16orf88, KNOP1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lysine-rich nucleolar protein 1
Names
family with sequence similarity 191, member A
protein C16orf88
testis-specific gene 118 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012991.3NP_001013009.2  lysine-rich nucleolar protein 1 isoform b

    See identical proteins and their annotated locations for NP_001013009.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2-6 all encode the same isoform (b).
    Source sequence(s)
    AC002550, BC117562
    Consensus CDS
    CCDS42127.1
    UniProtKB/Swiss-Prot
    Q1ED39
    Related
    ENSP00000219837.7, ENST00000219837.12
    Conserved Domains (1) summary
    pfam15477
    Location:362435
    SMAP; Small acidic protein family
  2. NM_001348527.2NP_001335456.1  lysine-rich nucleolar protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC002550
    Conserved Domains (1) summary
    pfam15477
    Location:422495
    SMAP; Small acidic protein family
  3. NM_001348528.2NP_001335457.1  lysine-rich nucleolar protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2-6 all encode the same isoform (b).
    Source sequence(s)
    AC002550
    Consensus CDS
    CCDS42127.1
    UniProtKB/Swiss-Prot
    Q1ED39
    Conserved Domains (1) summary
    pfam15477
    Location:362435
    SMAP; Small acidic protein family
  4. NM_001348529.2NP_001335458.1  lysine-rich nucleolar protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2-6 all encode the same isoform (b).
    Source sequence(s)
    AC002550
    Consensus CDS
    CCDS42127.1
    UniProtKB/Swiss-Prot
    Q1ED39
    Conserved Domains (1) summary
    pfam15477
    Location:362435
    SMAP; Small acidic protein family
  5. NM_001348530.2NP_001335459.1  lysine-rich nucleolar protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2-6 all encode the same isoform (b).
    Source sequence(s)
    AC002550
    Consensus CDS
    CCDS42127.1
    UniProtKB/Swiss-Prot
    Q1ED39
    Conserved Domains (1) summary
    pfam15477
    Location:362435
    SMAP; Small acidic protein family
  6. NM_001348531.2NP_001335460.1  lysine-rich nucleolar protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2-6 all encode the same isoform (b).
    Source sequence(s)
    AC002550
    Consensus CDS
    CCDS42127.1
    UniProtKB/Swiss-Prot
    Q1ED39
    Conserved Domains (1) summary
    pfam15477
    Location:362435
    SMAP; Small acidic protein family
  7. NM_001348532.2NP_001335461.1  lysine-rich nucleolar protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a. Variants 7-12 all encode the same isoform (c).
    Source sequence(s)
    AC002550
    Conserved Domains (1) summary
    pfam15477
    Location:339412
    SMAP; Small acidic protein family
  8. NM_001348533.2NP_001335462.1  lysine-rich nucleolar protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a. Variants 7-12 all encode the same isoform (c).
    Source sequence(s)
    AC002550
    Conserved Domains (1) summary
    pfam15477
    Location:339412
    SMAP; Small acidic protein family
  9. NM_001348534.2NP_001335463.1  lysine-rich nucleolar protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a. Variants 7-12 all encode the same isoform (c).
    Source sequence(s)
    AC002550
    Conserved Domains (1) summary
    pfam15477
    Location:339412
    SMAP; Small acidic protein family
  10. NM_001348535.2NP_001335464.1  lysine-rich nucleolar protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a. Variants 7-12 all encode the same isoform (c).
    Source sequence(s)
    AC002550
    Conserved Domains (1) summary
    pfam15477
    Location:339412
    SMAP; Small acidic protein family
  11. NM_001348536.2NP_001335465.1  lysine-rich nucleolar protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a. Variants 7-12 all encode the same isoform (c).
    Source sequence(s)
    AC002550
    Conserved Domains (1) summary
    pfam15477
    Location:339412
    SMAP; Small acidic protein family
  12. NM_001348537.2NP_001335466.1  lysine-rich nucleolar protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a. Variants 7-12 all encode the same isoform (c).
    Source sequence(s)
    AC002550
    Conserved Domains (1) summary
    pfam15477
    Location:339412
    SMAP; Small acidic protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    19701937..19718227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450278.1XP_024306046.1  lysine-rich nucleolar protein 1 isoform X1

    Conserved Domains (1) summary
    pfam15477
    Location:399472
    SMAP; Small acidic protein family
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