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BCAR4 breast cancer anti-estrogen resistance 4 [ Homo sapiens (human) ]

Gene ID: 400500, updated on 12-Mar-2019

Summary

Official Symbol
BCAR4provided by HGNC
Official Full Name
breast cancer anti-estrogen resistance 4provided by HGNC
Primary source
HGNC:HGNC:22170
See related
Ensembl:ENSG00000262117 MIM:613746
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]
Expression
Restricted expression toward placenta (RPKM 8.2) See more
Orthologs

Genomic context

See BCAR4 in Genome Data Viewer
Location:
16p13.13
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (11819830..11828832, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11913687..11922689, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 94 enhancer Neighboring gene thioredoxin domain containing 11 Neighboring gene zinc finger CCCH-type containing 7A Neighboring gene uncharacterized LOC105371084 Neighboring gene ribosomal L1 domain containing 1 Neighboring gene G1 to S phase transition 1 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

Other Names

  • breast cancer anti-estrogen resistance 4 (non-protein coding)
  • breast cancer antiestrogen resistance 4 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024049.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AC010654
    Related
    ENST00000573319.1
  2. NR_024050.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks two alternate exons compared to variant 1.
    Source sequence(s)
    AC010654, BX107175
    Related
    ENST00000571259.5
  3. NR_131216.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks two alternate exons compared to variant 1.
    Source sequence(s)
    BG573316, BX107175, H03167
  4. NR_131217.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks two alternate exons compared to variant 1.
    Source sequence(s)
    BG573316, BX107175
    Related
    ENST00000573037.1
  5. NR_131222.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site and lacks one alternate exon compared to variant 1.
    Source sequence(s)
    BG573316, BX107175, BX336046, R78073
    Related
    ENST00000571158.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    11819830..11828832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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