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HipHop HP1-HOAP-interacting protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40047, updated on 6-Jul-2026
Official Symbol
HipHopprovided by FlyBase
Official Full Name
HP1-HOAP-interacting proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036815
Locus tag
Dmel_CG6874
See related
AllianceGenome:FB:FBgn0036815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE10558; CG6874; Dmel\CG6874; hiphop; Hiphop; HIPHOP; l(3)neo26
Summary
Involved in CENP-A containing chromatin assembly and protection from non-homologous end joining at telomere. Located in chromosome, telomeric region. Is expressed in spermatocyte. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See HipHop in Genome Data Viewer
Location:
75E1-75E1; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18821171..18822353)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18814271..18815453)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ftz transcription factor 1 Neighboring gene long non-coding RNA:CR45939 Neighboring gene uncharacterized protein Neighboring gene Catalase Neighboring gene long non-coding RNA:CR32027 Neighboring gene I'm not dead yet

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taming active transposons at Drosophila telomeres: The interconnection between HipHop's roles in capping and transcriptional silencing.
    Title: Taming active transposons at Drosophila telomeres: The interconnection between HipHop's roles in capping and transcriptional silencing.
  2. Overexpression of Hiphop increased the survival of somatic cells with broken chromosomes. In the male germline, Hiphop overexpression greatly increased the transmission of healed chromosomes.
    Title: Chromosome Healing Is Promoted by the Telomere Cap Component Hiphop in Drosophila.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protection from non-homologous end joining at telomere IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protection from non-homologous end joining at telomere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome EXP
Inferred from Experiment
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of telomere cap complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
HP1-HOAP-interacting protein
Names
CG6874-PA
CG6874-PB
HP1 and HOAP-interacting protein
HP1-HOAP interacting protein
HipHop-PA
HipHop-PB
hiphop
l(3)neo26
lethal (3) neo26

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18821171..18822353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168777.2 → NP_730362.1  HP1-HOAP-interacting protein, isoform B

    See identical proteins and their annotated locations for NP_730362.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JWP6
    Related
    FBpp0074824

  2. NM_140804.3 → NP_649061.1  HP1-HOAP-interacting protein, isoform A

    See identical proteins and their annotated locations for NP_649061.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JWP6
    Related
    FBpp0074823
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JWP6 Q7JWP6
Q7JWP6.1

Gene LinkOut

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