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C14orf180 chromosome 14 open reading frame 180 [ Homo sapiens (human) ]

Gene ID: 400258, updated on 1-Aug-2020

Summary

Official Symbol
C14orf180provided by HGNC
Official Full Name
chromosome 14 open reading frame 180provided by HGNC
Primary source
HGNC:HGNC:33795
See related
Ensembl:ENSG00000184601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRAC; C14orf77
Expression
Biased expression in fat (RPKM 41.1) and heart (RPKM 22.1) See more
Orthologs

Genomic context

See C14orf180 in Genome Data Viewer
Location:
14q32.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (104579764..104590515)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105046056..105056184)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 684, pseudogene Neighboring gene cell cycle exit and neuronal differentiation 1 pseudogene 1 Neighboring gene transmembrane protein 179 Neighboring gene long intergenic non-protein coding RNA 2280

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nutritionally-regulated adipose and cardiac enriched protein homolog
Names
transmembrane protein C14orf180

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008404.3NP_001008404.1  nutritionally-regulated adipose and cardiac enriched protein homolog isoform b

    See identical proteins and their annotated locations for NP_001008404.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AK095913, AW451284, BX161457, BX927359
    Consensus CDS
    CCDS32166.1
    UniProtKB/Swiss-Prot
    Q8N912
    UniProtKB/TrEMBL
    A0A024R6Q4
    Related
    ENSP00000452502.1, ENST00000557649.5
    Conserved Domains (1) summary
    pfam15555
    Location:33155
    DUF4658; Domain of unknown function (DUF4658)
  2. NM_001286399.2NP_001273328.1  nutritionally-regulated adipose and cardiac enriched protein homolog isoform a

    See identical proteins and their annotated locations for NP_001273328.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK297818, AW451284, BX161457
    Consensus CDS
    CCDS66722.1
    UniProtKB/Swiss-Prot
    Q8N912
    UniProtKB/TrEMBL
    B4DN93, J3KNP8
    Related
    ENSP00000333041.2, ENST00000331952.6
    Conserved Domains (1) summary
    cl20010
    Location:33108
    Consortin_C; Consortin C-terminus
  3. NM_001286400.2NP_001273329.1  nutritionally-regulated adipose and cardiac enriched protein homolog isoform b

    See identical proteins and their annotated locations for NP_001273329.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AW451284, BX161457, BX927359
    Consensus CDS
    CCDS32166.1
    UniProtKB/Swiss-Prot
    Q8N912
    UniProtKB/TrEMBL
    A0A024R6Q4
    Related
    ENSP00000386487.1, ENST00000410013.1
    Conserved Domains (1) summary
    pfam15555
    Location:33155
    DUF4658; Domain of unknown function (DUF4658)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    104579764..104590515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536764.2XP_011535066.1  nutritionally-regulated adipose and cardiac enriched protein homolog isoform X1

    See identical proteins and their annotated locations for XP_011535066.1

    UniProtKB/TrEMBL
    J3KNP8
    Conserved Domains (1) summary
    cl20010
    Location:33108
    Consortin_C; Consortin C-terminus
  2. XM_005267638.3XP_005267695.1  nutritionally-regulated adipose and cardiac enriched protein homolog isoform X1

    See identical proteins and their annotated locations for XP_005267695.1

    UniProtKB/TrEMBL
    J3KNP8
    Conserved Domains (1) summary
    cl20010
    Location:33108
    Consortin_C; Consortin C-terminus

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187599.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    137587..148338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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