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Adgf-B Adenosine deaminase-related growth factor B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39975, updated on 2-Nov-2024

Summary

Official Symbol
Adgf-Bprovided by FlyBase
Official Full Name
Adenosine deaminase-related growth factor Bprovided by FlyBase
Primary source
FLYBASE:FBgn0036751
Locus tag
Dmel_CG5998
See related
AllianceGenome:FB:FBgn0036751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ADGF-B; adgfb; AdgfB; CG5998; Dmel\CG5998
Summary
Predicted to enable adenosine deaminase activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See Adgf-B in Genome Data Viewer
Location:
75A1-75A1; 3-45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17748833..17750588, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17741933..17743688, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ccn Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Adenosine deaminase-related growth factor A Neighboring gene Adenosine deaminase-related growth factor A2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables adenosine deaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in adenosine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenosine catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in adenosine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in inosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adenosine deaminase-related growth factor B
Names
Adgf-B-PA
CG5998-PA
NP_649006.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17748833..17750588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140749.2NP_649006.2  adenosine deaminase-related growth factor B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649006.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8ST69, Q9VVK4
    Related
    FBpp0074957, FBtr0075193
    Conserved Domains (3) summary
    cd01321
    Location:93507
    ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
    TIGR01431
    Location:56515
    adm_rel; adenosine deaminase-related growth factor
    pfam08451
    Location:36113
    A_deaminase_N; Adenosine/AMP deaminase N-terminal