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Tdpoz4 TD and POZ domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 399675, updated on 8-Feb-2024

Summary

Official Symbol
Tdpoz4provided by MGI
Official Full Name
TD and POZ domain containing 4provided by MGI
Primary source
MGI:MGI:3027904
See related
Ensembl:ENSMUSG00000060256 AllianceGenome:MGI:3027904
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of proteolysis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in early conceptus. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Tdpoz4 in Genome Data Viewer
Location:
3 F2.1; 3 40.51 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (93703705..93704817)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (93796398..93797510)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene TD and POZ domain containing pseudogene Neighboring gene STARR-seq mESC enhancer starr_08332 Neighboring gene TD and POZ domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08333 Neighboring gene TD and POZ domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_08334 Neighboring gene TD and POZ domain containing pseudogene

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
TD and POZ domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207272.2NP_997155.2  TD and POZ domain-containing protein 4

    See identical proteins and their annotated locations for NP_997155.2

    Status: PROVISIONAL

    Source sequence(s)
    AC130840
    Consensus CDS
    CCDS38528.1
    UniProtKB/Swiss-Prot
    E9QJY8, Q14BT0, Q6YCH2
    UniProtKB/TrEMBL
    A4FUR6
    Related
    ENSMUSP00000075338.2, ENSMUST00000075953.2
    Conserved Domains (4) summary
    smart00225
    Location:189287
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd14734
    Location:287349
    SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00651
    Location:180284
    BTB; BTB/POZ domain
    cl02446
    Location:16154
    MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    93703705..93704817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)