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SMIM10L2A small integral membrane protein 10 like 2A [ Homo sapiens (human) ]

Gene ID: 399668, updated on 12-Oct-2019

Summary

Official Symbol
SMIM10L2Aprovided by HGNC
Official Full Name
small integral membrane protein 10 like 2Aprovided by HGNC
Primary source
HGNC:HGNC:34499
See related
Ensembl:ENSG00000178947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LED; LINC0086; LINC00086; LINC00087; SMIM10L2B; NCRNA00086; NCRNA00087
Summary
This gene encodes a highly conserved small protein that contains a conserved motif (DUF4560) and may function as an integral membrane protein. This transcript was also shown to associate with enhancer chromatin and therefore may also function as an RNA to regulate enhancers. [provided by RefSeq, Jan 2017]
Expression
Biased expression in adrenal (RPKM 10.3), brain (RPKM 9.2) and 13 other tissues See more
Orthologs

Genomic context

See SMIM10L2A in Genome Data Viewer
Location:
Xq26.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (135421944..135428075)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134555868..134560225)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 449 Neighboring gene uncharacterized LOC100506790 Neighboring gene RNA, 5S ribosomal pseudogene 515 Neighboring gene CROCC pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General protein information

Preferred Names
small integral membrane protein 10-like protein 2A
Names
Small integral membrane protein 10-like protein 2B
lncRNA activator of enhancer domains
long intergenic non-protein coding RNA 86

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203306.3NP_976051.1  small integral membrane protein 10-like protein 2A

    Status: VALIDATED

    Source sequence(s)
    AL450472
    UniProtKB/Swiss-Prot
    P0DMW4, P0DMW5
    Related
    ENSP00000488643.1, ENST00000417443.3
    Conserved Domains (1) summary
    pfam15118
    Location:2177
    DUF4560; Domain of unknown function (DUF4560)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    135421944..135428075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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