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MEX3D mex-3 RNA binding family member D [ Homo sapiens (human) ]

Gene ID: 399664, updated on 3-May-2025
Official Symbol
MEX3Dprovided by HGNC
Official Full Name
mex-3 RNA binding family member Dprovided by HGNC
Primary source
HGNC:HGNC:16734
See related
Ensembl:ENSG00000181588 MIM:611009; AllianceGenome:HGNC:16734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEX3; TINO; RKHD1; MEX-3D; RNF193; OK/SW-cl.4
Summary
Enables mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in mRNA destabilization and mRNA localization resulting in post-transcriptional regulation of gene expression. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, May 2025]
Expression
Broad expression in testis (RPKM 6.0), fat (RPKM 4.9) and 24 other tissues See more
Orthologs
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See MEX3D in Genome Data Viewer
Location:
19p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1554672..1568325, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1525487..1539144, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1554671..1568324, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985337 Neighboring gene polo like kinase 5 (inactive) Neighboring gene CRISPRi-validated cis-regulatory element chr19.367 Neighboring gene MPRA-validated peak3222 silencer Neighboring gene Sharpr-MPRA regulatory region 1835 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9729 Neighboring gene RNA, 7SL, cytoplasmic 477, pseudogene Neighboring gene methyl-CpG binding domain protein 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584307-1584918 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1584919-1585529 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1590888-1591877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9732

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • KIAA2031

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
RNA-binding protein MEX3D
Names
RING finger and KH domain-containing protein 1
RING finger protein 193
bcl-2 ARE RNA binding protein
ring finger (C3HC4 type) and KH domain containing 1
ring finger and KH domain containing 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174118.2NP_001167589.1  RNA-binding protein MEX3D isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005943, AF458084
    UniProtKB/Swiss-Prot
    Q86XN8
    Conserved Domains (3) summary
    smart00322
    Location:273338
    KH; K homology RNA-binding domain
    cd00105
    Location:180241
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam13920
    Location:598645
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_203304.4NP_976049.3  RNA-binding protein MEX3D isoform 1

    See identical proteins and their annotated locations for NP_976049.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC005943, AC027307
    Consensus CDS
    CCDS32865.2
    UniProtKB/Swiss-Prot
    A0PJL8, A1L023, E9PAL6, Q71M49, Q86XN8
    Related
    ENSP00000384398.3, ENST00000402693.5
    Conserved Domains (3) summary
    smart00322
    Location:273338
    KH; K homology RNA-binding domain
    cd00105
    Location:180241
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam13920
    Location:598645
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    1554672..1568325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    1525487..1539144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)