Format

Send to:

Choose Destination

Flrt2 fibronectin leucine rich transmembrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 399558, updated on 25-Sep-2020

Summary

Official Symbol
Flrt2provided by MGI
Official Full Name
fibronectin leucine rich transmembrane protein 2provided by MGI
Primary source
MGI:MGI:3603594
See related
Ensembl:ENSMUSG00000047414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Broad expression in limb E14.5 (RPKM 8.9), CNS E14 (RPKM 5.0) and 17 other tissues See more
Orthologs

Genomic context

See Flrt2 in Genome Data Viewer
Location:
12; 12 E
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (95658780..95751989)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (95692006..95785215)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (96930436..97023425)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22246 Neighboring gene ribosomal protein L17, pseudogene 2 Neighboring gene RIKEN cDNA 1700019M22 gene Neighboring gene nascent polypeptide-associated complex alpha polypeptide pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0405

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chemorepellent activity IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
basement membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell adhesion involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat transmembrane protein FLRT2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201518.4NP_958926.1  leucine-rich repeat transmembrane protein FLRT2 precursor

    See identical proteins and their annotated locations for NP_958926.1

    Status: VALIDATED

    Source sequence(s)
    AC122430, AC125487
    Consensus CDS
    CCDS26094.1
    UniProtKB/Swiss-Prot
    Q8BLU0
    Related
    ENSMUSP00000062171.3, ENSMUST00000057324.3
    Conserved Domains (7) summary
    smart00013
    Location:3566
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:310361
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:110289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:6586
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252311
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    95658780..95751989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244132.3XP_011242434.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

    See identical proteins and their annotated locations for XP_011242434.1

    UniProtKB/Swiss-Prot
    Q8BLU0
    Conserved Domains (7) summary
    smart00013
    Location:3566
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:310361
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:110289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:6586
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252311
    LRR_8; Leucine rich repeat
  2. XM_036157517.1XP_036013410.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

  3. XM_006516055.4XP_006516118.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

    See identical proteins and their annotated locations for XP_006516118.1

    UniProtKB/Swiss-Prot
    Q8BLU0
    Related
    ENSMUSP00000105744.1, ENSMUST00000110117.1
    Conserved Domains (7) summary
    smart00013
    Location:3566
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:310361
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:110289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:6586
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252311
    LRR_8; Leucine rich repeat
  4. XM_036157518.1XP_036013411.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

Support Center