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Flrt2 fibronectin leucine rich transmembrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 399558, updated on 3-May-2022

Summary

Official Symbol
Flrt2provided by MGI
Official Full Name
fibronectin leucine rich transmembrane protein 2provided by MGI
Primary source
MGI:MGI:3603594
See related
Ensembl:ENSMUSG00000047414 AllianceGenome:MGI:3603594
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables chemorepellent activity and fibroblast growth factor receptor binding activity. Involved in basement membrane organization; cell adhesion involved in heart morphogenesis; and fibroblast growth factor receptor signaling pathway. Acts upstream of or within axon guidance; positive regulation of synapse assembly; and regulation of neuron migration. Located in cell-cell junction and extracellular space. Is integral component of plasma membrane. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system epithelium; branchial arch; central nervous system; embryo mesenchyme; and sensory organ. Orthologous to human FLRT2 (fibronectin leucine rich transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 8.9), CNS E14 (RPKM 5.0) and 17 other tissues See more
Orthologs
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Genomic context

See Flrt2 in Genome Data Viewer
Location:
12; 12 E
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (95658780..95751989)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (95692006..95785215)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (96930436..97023425)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22246 Neighboring gene ribosomal protein L17, pseudogene 2 Neighboring gene RIKEN cDNA 1700019M22 gene Neighboring gene nascent polypeptide-associated complex alpha polypeptide pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0405

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat transmembrane protein FLRT2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201518.4NP_958926.1  leucine-rich repeat transmembrane protein FLRT2 precursor

    See identical proteins and their annotated locations for NP_958926.1

    Status: VALIDATED

    Source sequence(s)
    AC122430, AC125487
    Consensus CDS
    CCDS26094.1
    UniProtKB/Swiss-Prot
    Q8BLU0
    Related
    ENSMUSP00000062171.4, ENSMUST00000057324.4
    Conserved Domains (6) summary
    PRK15370
    Location:26265
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:282359
    PCC; polycystin cation channel protein
    sd00031
    Location:6586
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252311
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    95658780..95751989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244132.3XP_011242434.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

    See identical proteins and their annotated locations for XP_011242434.1

    UniProtKB/Swiss-Prot
    Q8BLU0
    Conserved Domains (6) summary
    PRK15370
    Location:26265
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:282359
    PCC; polycystin cation channel protein
    sd00031
    Location:6586
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252311
    LRR_8; Leucine rich repeat
  2. XM_036157517.1XP_036013410.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

    Conserved Domains (6) summary
    PRK15370
    Location:26265
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:282359
    PCC; polycystin cation channel protein
    sd00031
    Location:6586
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252311
    LRR_8; Leucine rich repeat
  3. XM_006516055.4XP_006516118.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

    See identical proteins and their annotated locations for XP_006516118.1

    UniProtKB/Swiss-Prot
    Q8BLU0
    Related
    ENSMUSP00000105744.2, ENSMUST00000110117.2
    Conserved Domains (6) summary
    PRK15370
    Location:26265
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:282359
    PCC; polycystin cation channel protein
    sd00031
    Location:6586
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252311
    LRR_8; Leucine rich repeat
  4. XM_036157518.1XP_036013411.1  leucine-rich repeat transmembrane protein FLRT2 isoform X1

    Conserved Domains (6) summary
    PRK15370
    Location:26265
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:282359
    PCC; polycystin cation channel protein
    sd00031
    Location:6586
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:90110
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00041
    Location:426494
    fn3; Fibronectin type III domain
    pfam13855
    Location:252311
    LRR_8; Leucine rich repeat