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VWF von Willebrand factor [ Sus scrofa (pig) ]

Gene ID: 399543, updated on 26-Jun-2026
Official Symbol
VWFprovided by VGNC
Official Full Name
von Willebrand factorprovided by VGNC
Primary source
VGNC:VGNC:104094
See related
Ensembl:ENSSSCG00000000712 RGD:14063466
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Broad expression in lung (RPKM 62.6), subcutaneous adipose (RPKM 42.5) and 7 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See VWF in Genome Data Viewer
Location:
chromosome: 5
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2026_06 current Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0 (GCF_054392235.1) 5 NC_139387.1 (71499938..71639178)
106 previous assembly Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (64516627..64655938)

Chromosome 5 - NC_139387.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC146403440 Neighboring gene uncharacterized LOC106508508 Neighboring gene CD9 molecule Neighboring gene anoctamin 2 Neighboring gene neurotrophin 3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A 12.3-kb Duplication Within the VWF Gene in Pigs Affected by Von Willebrand Disease Type 3. Lehner S, et al. G3 (Bethesda), 2018 Feb 2. PMID 29208651, Free PMC Article
  2. O-linked glycosylation and functional incompatibility of porcine von Willebrand factor for human platelet GPIb receptors. Schulte Am Esch J 2nd, et al. Xenotransplantation, 2005 Jan. PMID 15598271
  3. Comparison of the primary structure of the functional domains of human and porcine von Willebrand factor that mediate platelet adhesion. Bahnak BR, et al. Biochem Biophys Res Commun, 1992 Jan 31. PMID 1370885
  4. FISH mapping of the porcine vWF gene to chromosome 5q21 extends synteny homology with human chromosome 12. Sjöberg A, et al. Hereditas, 1996. PMID 8782436
  5. Primary structure of the factor VIII binding domain of human, porcine and rabbit von Willebrand factor. Lavergne JM, et al. Biochem Biophys Res Commun, 1993 Aug 16. PMID 8352759

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In conclusion, endothelial vWF knockdown prevented angiotensin II-induced ET-1 upregulation through attenuation of NOX-mediated O2- production.
    Title: Gene silencing of endothelial von Willebrand Factor attenuates angiotensin II-induced endothelin-1 expression in porcine aortic endothelial cells.
  2. alterations in glycosylation of vWF and other adhesion proteins associated with the targeting of the alpha1,3-Gal-epitope in mutant swine may have salutatory effects on the primate platelet activation observed in these xenografts.
    Title: O-linked glycosylation and functional incompatibility of porcine von Willebrand factor for human platelet GPIb receptors.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
von Willebrand factor
Names
von Willebrand factor preproprotein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001246221.1 → NP_001233150.1  von Willebrand factor precursor

    See identical proteins and their annotated locations for NP_001233150.1

    Status: PROVISIONAL

    Source sequence(s)
    BK007995
    UniProtKB/TrEMBL
    A0A2Z2YPW6, F5XVC2
    Related
    ENSSSCP00000000759.3, ENSSSCT00000000775.5
    Conserved Domains (11) summary
    smart00041
    Location:2722 → 2802
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00214
    Location:2425 → 2488
    VWC; von Willebrand factor (vWF) type C domain
    smart00216
    Location:376 → 539
    VWD; von Willebrand factor (vWF) type D domain
    smart00327
    Location:1272 → 1444
    VWA; von Willebrand factor (vWF) type A domain
    smart00832
    Location:1052 → 1126
    C8; This domain contains 8 conserved cysteine residues
    pfam00092
    Location:1492 → 1652
    VWA; von Willebrand factor type A domain
    pfam00094
    Location:1944 → 2096
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:651 → 706
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:2132 → 2193
    C8; C8 domain
    pfam16164
    Location:1197 → 1271
    VWA_N2; VWA N-terminal
    cl17735
    Location:2576 → 2638
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_054392235.1-RS_2026_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

Genomic

  1. NC_139387.1 Reference Sscrofa_HxYL_maternal_Yorkshire_Landrace_v2.0

    Range
    71499938..71639178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28833.2 GenPept UniProtKB/Swiss-Prot:Q28833

Gene LinkOut

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