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SUCLG1 succinate-CoA ligase GDP/ADP-forming subunit alpha [ Sus scrofa (pig) ]

Gene ID: 399539, updated on 9-Feb-2026
Official Symbol
SUCLG1provided by VGNC
Official Full Name
succinate-CoA ligase GDP/ADP-forming subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:93603
See related
Ensembl:ENSSSCG00000008247 RGD:14061101
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
SCS
Expression
Ubiquitous expression in heart (RPKM 307.0), psoas major muscle (RPKM 235.7) and 8 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See SUCLG1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (60142340..60177497)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (63138718..63174813)

Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene TraB domain containing 2A Neighboring gene dynein axonemal heavy chain 6 Neighboring gene cytokine receptor-like factor 3 Neighboring gene uncharacterized LOC110260136

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Related articles in PubMed

  1. Structural basis for the binding of succinate to succinyl-CoA synthetase. Huang J, et al. Acta Crystallogr D Struct Biol, 2016 Aug. PMID 27487822
  2. Structure of GTP-specific succinyl-CoA synthetase in complex with CoA. Huang J, et al. Acta Crystallogr F Struct Biol Commun, 2015 Aug. PMID 26249701, Free PMC Article
  3. Interactions of GTP with the ATP-grasp domain of GTP-specific succinyl-CoA synthetase. Fraser ME, et al. J Biol Chem, 2006 Apr 21. PMID 16481318
  4. Mutually exclusive splicing generates two distinct isoforms of pig heart succinyl-CoA synthetase. Ryan DG, et al. J Biol Chem, 1997 Aug 22. PMID 9261120
  5. Phosphorylated and dephosphorylated structures of pig heart, GTP-specific succinyl-CoA synthetase. Fraser ME, et al. J Mol Biol, 2000 Jun 23. PMID 10873456

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pig GTP-specific succinyl-CoA synthetase was crystallized in the presence of succinate, magnesium ions and CoA, and the structure of the complex was determined by X-ray crystallography to 2.2 A resolution. Succinate binds in the carboxy-terminal domain of the beta-subunit.
    Title: Structural basis for the binding of succinate to succinyl-CoA synthetase.
  2. Structure of GTP-specific succinyl-CoA synthetase subunits in complex with CoA has been resolved.
    Title: Structure of GTP-specific succinyl-CoA synthetase in complex with CoA.
  3. succinyl-CoA synthetase is able to protect GTP from hydrolysis when the active-site histidine residue is not in position to be phosphorylated
    Title: Interactions of GTP with the ATP-grasp domain of GTP-specific succinyl-CoA synthetase.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables succinate-CoA ligase (ADP-forming) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables succinate-CoA ligase (GDP-forming) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of succinate-CoA ligase complex (ADP-forming) IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Names
SCS-alpha
itaconyl--CoA ligase [ADP/GDP-forming] subunit alpha
malyl--CoA ligase [ADP/GDP-forming] subunit alpha
succinate-CoA ligase alpha subunit
succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
succinyl-CoA synthetase alpha subunit
succinyl-CoA synthetase subunit alpha
NP_999574.1
XP_005655282.2
XP_020941544.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214409.2 → NP_999574.1  succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

    See identical proteins and their annotated locations for NP_999574.1

    Status: PROVISIONAL

    Source sequence(s)
    AF008589
    UniProtKB/TrEMBL
    A0A4X1W694, A0A5G2QM57
    Related
    ENSSSCP00000063182.2, ENSSSCT00000087214.2
    Conserved Domains (3) summary
    PTZ00187
    Location:6 → 348
    PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
    pfam02629
    Location:40 → 133
    CoA_binding; CoA binding domain
    cl22543
    Location:203 → 328
    Ligase_CoA; CoA-ligase

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

    Range
    60142340..60177497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005655225.2 → XP_005655282.2  succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A480U8Y2, A0A4X1W6L5, A0A8D1D8T8, F1SNZ6
    Related
    ENSSSCP00000008807.5, ENSSSCT00000009033.5
    Conserved Domains (1) summary
    PTZ00187
    Location:19 → 344
    PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional

  2. XM_021085885.1 → XP_020941544.1  succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8D1D8T8
    Conserved Domains (1) summary
    PTZ00187
    Location:97 → 398
    PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O19069.2 GenPept UniProtKB/Swiss-Prot:O19069

Gene LinkOut

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