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SLC25A35 solute carrier family 25 member 35 [ Homo sapiens (human) ]

Gene ID: 399512, updated on 7-Jun-2020

Summary

Official Symbol
SLC25A35provided by HGNC
Official Full Name
solute carrier family 25 member 35provided by HGNC
Primary source
HGNC:HGNC:31921
See related
Ensembl:ENSG00000125434 MIM:610818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
SLC25A35 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 9.0), endometrium (RPKM 4.9) and 24 other tissues See more
Orthologs

Genomic context

See SLC25A35 in Genome Data Viewer
Location:
17p13.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8287763..8295689, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8191082..8198709, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-Ile (anticodon AAT) 4-1 Neighboring gene CST telomere replication complex component 1 Neighboring gene phosphoribosylformylglycinamidine synthase Neighboring gene RAN guanine nucleotide release factor Neighboring gene CRISPRi-validated cis-regulatory element chr17.641 Neighboring gene Rho guanine nucleotide exchange factor 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40217, MGC120446, MGC120448

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 25 member 35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320870.2NP_001307799.1  solute carrier family 25 member 35 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC135178, BC041597, BC105995, BM987725
    Consensus CDS
    CCDS82067.1
    UniProtKB/Swiss-Prot
    Q3KQZ1
    Related
    ENSP00000464231.1, ENST00000577745.2
    Conserved Domains (1) summary
    pfam00153
    Location:209298
    Mito_carr; Mitochondrial carrier protein
  2. NM_001320871.2NP_001307800.1  solute carrier family 25 member 35 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' structure compared to variant 1. The encoded isoform (b) has a distinct C-terminus, and is shorter than isofom a. Variants 2 through 4 encodes the same isoform.
    Source sequence(s)
    AC135178, BC052233
    Consensus CDS
    CCDS11138.1
    UniProtKB/Swiss-Prot
    Q3KQZ1
    Related
    ENSP00000462395.1, ENST00000579192.5
    Conserved Domains (2) summary
    pfam00153
    Location:284
    Mito_carr; Mitochondrial carrier protein
    cl28162
    Location:119194
    Mito_carr; Mitochondrial carrier protein
  3. NM_001320872.1NP_001307801.1  solute carrier family 25 member 35 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' structure compared to variant 1. The encoded isoform (b) has a distinct C-terminus, and is shorter than isofom a. Variants 2 through 4 encodes the same isoform.
    Source sequence(s)
    BC052233, BC101329, BC101330
    Consensus CDS
    CCDS11138.1
    UniProtKB/Swiss-Prot
    Q3KQZ1
    Related
    ENSP00000464071.1, ENST00000580340.5
    Conserved Domains (2) summary
    pfam00153
    Location:284
    Mito_carr; Mitochondrial carrier protein
    cl28162
    Location:119194
    Mito_carr; Mitochondrial carrier protein
  4. NM_001320877.1NP_001307806.1  solute carrier family 25 member 35 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a
    Source sequence(s)
    AC135178
    Conserved Domains (1) summary
    pfam00153
    Location:187276
    Mito_carr; Mitochondrial carrier protein
  5. NM_201520.3NP_958928.1  solute carrier family 25 member 35 isoform b

    See identical proteins and their annotated locations for NP_958928.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' structure compared to variant 1. The encoded isoform (b) has a distinct C-terminus, and is shorter than isofom a. Variants 2 through 4 encodes the same isoform.
    Source sequence(s)
    AC135178, AK097536, BC041597
    Consensus CDS
    CCDS11138.1
    UniProtKB/Swiss-Prot
    Q3KQZ1
    Related
    ENSP00000369407.2, ENST00000380067.6
    Conserved Domains (2) summary
    pfam00153
    Location:284
    Mito_carr; Mitochondrial carrier protein
    cl28162
    Location:119194
    Mito_carr; Mitochondrial carrier protein

RNA

  1. NR_135483.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC135178, AY498866, BC052233, BC101330
  2. NR_135484.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC052233, BC101330

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8287763..8295689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523846.2XP_011522148.1  solute carrier family 25 member 35 isoform X1

    See identical proteins and their annotated locations for XP_011522148.1

    UniProtKB/Swiss-Prot
    Q3KQZ1
    Related
    ENSP00000464191.1, ENST00000585311.5
    Conserved Domains (2) summary
    pfam00153
    Location:284
    Mito_carr; Mitochondrial carrier protein
    cl28162
    Location:209286
    Mito_carr; Mitochondrial carrier protein
  2. XM_005256641.3XP_005256698.1  solute carrier family 25 member 35 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:158247
    Mito_carr; Mitochondrial carrier protein
  3. XM_024450748.1XP_024306516.1  solute carrier family 25 member 35 isoform X3

    Conserved Domains (1) summary
    pfam00153
    Location:284
    Mito_carr; Mitochondrial carrier protein
  4. XM_017024634.2XP_016880123.1  solute carrier family 25 member 35 isoform X4

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