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mapk3 mitogen-activated protein kinase 3 [ Danio rerio (zebrafish) ]

Gene ID: 399480, updated on 18-Sep-2024

Summary

Official Symbol
mapk3provided by ZNC
Official Full Name
mitogen-activated protein kinase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040121-1
See related
Ensembl:ENSDARG00000070573 AllianceGenome:ZFIN:ZDB-GENE-040121-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ERK1; zERK1; fi06b09; wu:fi06b09
Summary
Predicted to enable MAP kinase activity. Acts upstream of or within central nervous system development; chordate embryonic development; and eye development. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including EVL; brain; cranium; digestive system; and heart. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See mapk3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26211974..26222308, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (26081103..26091437, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene yippee-like 3 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3a Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 9 Neighboring gene protein phosphatase 4, catalytic subunit a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 3
NP_958915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201507.1NP_958915.1  mitogen-activated protein kinase 3

    See identical proteins and their annotated locations for NP_958915.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045505
    UniProtKB/TrEMBL
    B2GNH0, Q7ZVK8
    Related
    ENSDARP00000094521.4, ENSDART00000103746.6
    Conserved Domains (2) summary
    smart00220
    Location:56344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07849
    Location:50384
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    26211974..26222308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)